This work presents 3-D Finite Element Model of the heat transfer inside granite during pulsed laser ablation with the aim of achieving laser cleaning treatment without damaging the stone surface. The model is focused on biotite, the most affected granite-forming mineral, owing to its low melting temperature. The model predicts sizes of the molten region that are consistent with experimental results. Moreover, the effects of different irradiation parameters; i.e., fluence, laser repetition frequency, and speed of scan have been investigated through the size of the biotite molten region. This model may be considered as the first stage of a comprehensive model of the laser ablation process in granite.