Phenotypic changes in mouse leukemia L1210 cells with alterations in the effector-binding subunit of ribonucleotide reductase

2000 ◽  
Vol 40 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Joseph G Cory ◽  
Lilla Somerville ◽  
Ai-Wu Ruth He ◽  
Ann H Cory
Keyword(s):  
Ribonucleotide Reductase ◽  
Mouse Leukemia ◽  
Phenotypic Changes ◽  
L1210 Cells ◽  
Effector Binding ◽  
Binding Subunit

scholarly journals Inhibition of ribonucleotide reductase and growth of human colon carcinoma HT-29 cells and mouse leukemia L1210 cells by N-hydroxy-N′-aminoguanidine derivatives

1990 ◽  
Vol 40 (8) ◽  
pp. 1779-1783 ◽  
Author(s):  
Matsumoto Masahiko ◽  
John G. Fox ◽  
Wang Pou-Hsiung ◽  
Phanesh B. Koneru ◽  
Eric J. Lien ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Ribonucleotide Reductase ◽  
Human Colon ◽  
Mouse Leukemia ◽  
L1210 Cells ◽  
Human Colon Carcinoma ◽  
Ht 29

Alterations in the components of ribonucleotide reductase in hydroxyurea-resistant hamster cells

1983 ◽  
Vol 3 (8) ◽  
pp. 741-748 ◽  
Author(s):  
Jim A. Wright ◽  
Joseph G. Cory
Keyword(s):  
Ribonucleotide Reductase ◽  
Reductase Activity ◽  
Antitumor Agent ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Wild Type ◽  
Type Analysis ◽  
Similar Mode ◽  
Ribonucleotide Reductase Activity ◽  
Effector Binding

Two components of mammalian ribonucleotide reductase have been separated by blue dextran-Sepharose chromatography from a hydroxyurea-resistant cell line, NcR-30A2, and its parental wild type. Analysis of reductase activity in these cells and the enzyme components reveals that there are three alterations involving ribonucleotide reductase activity in NcR-30A2 cells. There is an elevation in the effector-binding (EB) component, an elevation in the non-heine-ironcontaining (NHI) component, and an alteration in the NHI component that renders the enzyme less sensitive to inhibition by hydroxyurea. These findings easily account for the resistance of NcR-30A2 cells to the antitumor agent hydroxyurea, and to other drugs with a similar mode of action.

scholarly journals Cross-talk between the Allosteric Effector-binding Sites in Mouse Ribonucleotide Reductase

2000 ◽  
Vol 275 (42) ◽  
pp. 33021-33026 ◽  
Author(s):  
Peter Reichard ◽  
Rolf Eliasson ◽  
Rolf Ingemarson ◽  
Lars Thelander
Keyword(s):  
Cross Talk ◽  
Ribonucleotide Reductase ◽  
Binding Sites ◽  
Allosteric Effector ◽  
Effector Binding

HPLC behavior and cytotoxic activity against mouse leukemia L1210 cells of platinum pyrimidine greens

1990 ◽  
Vol 167 (2) ◽  
pp. 153-155 ◽  
Author(s):  
Takehiko Shimura ◽  
Takenori Tomohiro ◽  
Tomoko Okada ◽  
Hiroaki (Yohmei) Okuno
Keyword(s):  
Cytotoxic Activity ◽  
Mouse Leukemia ◽  
L1210 Cells

Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium

1982 ◽  
Vol 31 (20) ◽  
pp. 3261-3267 ◽  
Author(s):  
Leonard A. Zwelling ◽  
Stephen Michaels ◽  
Donna Kerrigan ◽  
Yves Pommier ◽  
Kurt W. Kohn
Keyword(s):  
Deoxyribonucleic Acid ◽  
Mouse Leukemia ◽  
Strand Breaks ◽  
L1210 Cells

The role of methionine in methotrexate-sensitive and methotrexate-resistant mouse leukemia L1210 cells

1987 ◽  
Vol 19 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Kevin J Scanlon ◽  
Mohammed Kashani-Sabet ◽  
Arlene R. Cashmore ◽  
Michele Pallai ◽  
Barbara A. Moroson ◽  
...  
Keyword(s):  
Resistant Mouse ◽  
Mouse Leukemia ◽  
L1210 Cells

Mechanistic aspects of the cytocidal action of ulithiacyclamide on mouse leukemia L1210 cells in vitro

1989 ◽  
Vol 38 (24) ◽  
pp. 4497-4500 ◽  
Author(s):  
Kohda Kohfuku ◽  
Ohta Yuko ◽  
Yokoyama Yumi ◽  
Kawazoe Yutaka ◽  
Kato Taketoshi ◽  
...  
Keyword(s):  
Mouse Leukemia ◽  
L1210 Cells
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