Chapter 19. Recent advances in therapeutic approaches to type 2 diabetes

Author(s):  
John M. Nuss ◽  
Allan S. Wagman
2021 ◽  
Vol 11 (2) ◽  
pp. 45-46
Author(s):  
Ahed J Alkhatib

The diabetes as a disease has been reported for 3500 years. Although diagnostic and therapeutic approaches have continuously developed, no definitive therapeutic approaches have so far been reached. Diabetes is not a single disease; it interferes with various systems in the body including nervous system and cardiovascular system. The therapeutic lines for type 1 diabetes start with insulin and will need another treatment such as metformin. On the other hand, type 2 diabetes treatment strategies start with metformin and there will be a need for another treatment, insulin according to the disease progression. At certain point, both types of diabetes are treated applying the same strategies. In this study, we followed another strategy by applying the use of apple cider vinegar in patient with type 1 diabetes, and patient with type 2 diabetes following getting each meal. The results showed that glucose levels were within reference range after five days. Taken together, the use of apple cider vinegar as a secondary treatment line with conventional diabetic treatment is promising and needs to be further investigated


Peptides ◽  
2021 ◽  
pp. 170652
Author(s):  
J. Michael Conlon ◽  
Peter R. Flatt ◽  
Clifford J. Bailey

2020 ◽  
Vol 13 ◽  
pp. 117955142090584 ◽  
Author(s):  
Annie Hasib

The ever-increasing prevalence of obesity and Type 2 diabetes has necessitated the development of newer and more effective approaches for achieving efficient glycemic control and weight loss. Conventional treatment methods often result in weight gain, further deteriorating the already impaired metabolic control in people with obesity/Type 2 diabetes. Alleviation of obesity and diabetes achieved after bariatric surgeries highlight the therapeutic importance of gut-brain axis and entails development of more patient-friendly approaches replicating the positive metabolic effects of bariatric surgery. Given the potential involvement of several gut hormones in the success of bariatric surgery, the therapeutic importance of synergistic interaction between these hormones for improved metabolism cannot be ignored. Many unimolecular multiagonist peptides are in preclinical and clinical trials as they maximize the combinatorial metabolic efficacy by concurrent activation of multiple gut hormone receptors. This review summarizes the ongoing developments of multiagonist peptides as novel therapeutic approaches against obesity-diabetes.


2006 ◽  
Vol 57 (1) ◽  
pp. 265-281 ◽  
Author(s):  
Laurie L. Baggio ◽  
Daniel J. Drucker

2008 ◽  
Vol 84 (996) ◽  
pp. 524-531 ◽  
Author(s):  
B T Srinivasan ◽  
J Jarvis ◽  
K Khunti ◽  
M J Davies

2014 ◽  
Vol 11 (11) ◽  
pp. 1185-1200 ◽  
Author(s):  
Yanling Wu ◽  
Yanping Ding ◽  
Yoshimasa Tanaka ◽  
Wen Zhang

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