The Subfornical Organ

1979 ◽  
pp. 333-421 ◽  
Author(s):  
H. Dieter Dellmann ◽  
John B. Simpson
Keyword(s):  
Subfornical Organ

Regional differences in the morphology of the rat subfornical organ

1976 ◽  
Vol 116 (3) ◽  
pp. 389-400 ◽  
Author(s):  
H.-D. Dellmann ◽  
J.B. Simpson
Keyword(s):  
Regional Differences ◽  
Subfornical Organ

scholarly journals Water permeability of capillaries in the subfornical organ of rats determined by Gd‐DTPA 2‐ enhanced 1 H magnetic resonance imaging

2002 ◽  
Vol 545 (1) ◽  
pp. 217-228 ◽  
Author(s):  
Yoshiteru Seo ◽  
Akira Takamata ◽  
Takashi Ogino ◽  
Hironobu Morita ◽  
Shun Nakamura ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Water Permeability ◽  
Subfornical Organ ◽  
Resonance Imaging

scholarly journals Subfornical organ neurons integrate cardiovascular and metabolic signals

2017 ◽  
Vol 312 (2) ◽  
pp. R253-R262 ◽  
Author(s):  
Nicole M. Cancelliere ◽  
Alastair V. Ferguson
Keyword(s):  
Patch Clamp ◽  
Subfornical Organ ◽  
Ang Ii ◽  
Metabolic Homeostasis ◽  
Circumventricular Organ ◽  
Autonomic Functions ◽  
Bath Application ◽  
Metabolic Signal ◽  
Metabolic Hormone

The subfornical organ (SFO) is a critical circumventricular organ involved in the control of cardiovascular and metabolic homeostasis. Despite the plethora of circulating signals continuously sensed by the SFO, studies investigating how these signals are integrated are lacking. In this study, we use patch-clamp techniques to investigate how the traditionally classified “cardiovascular” hormone ANG II, “metabolic” hormone CCK and “metabolic” signal glucose interact and are integrated in the SFO. Sequential bath application of CCK (10 nM) and ANG (10 nM) onto dissociated SFO neurons revealed that 63% of responsive SFO neurons depolarized to both CCK and ANG; 25% depolarized to ANG only; and 12% hyperpolarized to CCK only. We next investigated the effects of glucose by incubating and recording neurons in either hypoglycemic, normoglycemic, or hyperglycemic conditions and comparing the proportions of responses to ANG ( n = 55) or CCK ( n = 83) application in each condition. A hyperglycemic environment was associated with a larger proportion of depolarizing responses to ANG ( χ2, P < 0.05), and a smaller proportion of depolarizing responses along with a larger proportion of hyperpolarizing responses to CCK ( χ2, P < 0.01). Our data demonstrate that SFO neurons excited by CCK are also excited by ANG and that glucose environment affects the responsiveness of neurons to both of these hormones, highlighting the ability of SFO neurons to integrate multiple metabolic and cardiovascular signals. These findings have important implications for this structure’s role in the control of various autonomic functions during hyperglycemia.

scholarly journals Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension

Hypertension ◽  
2013 ◽  
Vol 61 (3) ◽  
pp. 716-722 ◽  
Author(s):  
Aline M. Hilzendeger ◽  
Martin D. Cassell ◽  
Deborah R. Davis ◽  
Harald M. Stauss ◽  
Allyn L. Mark ◽  
...  
Keyword(s):  
Subfornical Organ ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
Angiotensin Type
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