Margin status post cervical conization predicts residual adenocarcinoma in situ and occult adenocarcinoma

2021 ◽  
Vol 162 ◽  
pp. S203-S204
Author(s):  
Linda Hong ◽  
Sandy Huynh ◽  
Joy Kim ◽  
Laura Denham ◽  
Yevgeniya Ioffe
Keyword(s):  
Margin Status ◽  
Adenocarcinoma In Situ ◽  
Cervical Conization

scholarly journals Margin Status Post Cervical Conization Predicts Residual Adenocarcinoma In Situ (AIS) and Occult Adenocarcinoma in a Predominantly Hispanic Population

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1889
Author(s):  
Linda J. Hong ◽  
Sandy Huynh ◽  
Joy Kim ◽  
Laura Denham ◽  
Mazdak Momeni ◽  
...  
Keyword(s):  
Residual Disease ◽  
Margin Status ◽  
Invasive Cancer ◽  
Comprehensive Cancer Center ◽  
Adenocarcinoma In Situ ◽  
Hispanic Population ◽  
Positive Margins ◽  
Predominantly Hispanic ◽  
Cervical Conization

Background: Adenocarcinoma in situ (AIS) of the cervix, is increasing in incidence, particularly in women of reproductive age. Fertility preservation is often desired. In a predominantly Hispanic population, we sought to determine the incidence of occult cervical cancer co-existing with AIS, and evaluate how conization margin status correlates with residual disease upon hysterectomy. Methods: A retrospective study utilizing a comprehensive cancer center database was conducted. Data from patients with histologically proven AIS of the cervix were abstracted. Results: Of 47 patients that met the criteria, 23 (49%) were Hispanic, 21 (45%) were White, two (4%) were Asian, and one (2%) was Black. The median age was 37. Forty-two patients underwent cervical conizations; 13/42 (48%) had positive margins upon conization; 28/42 (67%) underwent hysterectomies. Furthermore, 6/13 (46%) patients with positive conization margins had residual disease in hysterectomy specimens, with 2/13 (15%) found to have invasive cancer. In contrast, 0/14 (0%) of patients with negative margins had residual disease (p = 0.036, Chi-squared 4.41, df = 1). In total, 2/27 (7%) patients who underwent hysterectomies had invasive cancer (7%). Conclusions: Positive margins upon cervical conization for AIS of the cervix were correlated with a relatively high rate of residual AIS and occult invasive cancer. Negative conization margins were correlated with no residual disease. Those patients may be candidates for fertility-sparing treatment.

Cervical conization of adenocarcinoma in situ: a predicting model of residual disease

2014 ◽  
Vol 210 (4) ◽  
pp. 366.e1-366.e5 ◽  
Author(s):  
Katherine E. Tierney ◽  
Paul S. Lin ◽  
Charles Amezcua ◽  
Koji Matsuo ◽  
Wei Ye ◽  
...  
Keyword(s):  
Residual Disease ◽  
Adenocarcinoma In Situ ◽  
Predicting Model ◽  
Cervical Conization

scholarly journals Case Report About Extraperitoneal Metastasis of Cervical Adenocarcinoma In Situ

2021 ◽  
Author(s):  
Aiwen Le ◽  
Lirong Han ◽  
Peng Wang ◽  
Kai Kang
Keyword(s):  
Intraepithelial Neoplasia ◽  
Adenocarcinoma In Situ ◽  
Retroperitoneal Mass ◽  
Cancer Antigen 125 ◽  
Case Presentation ◽  
Cin Iii ◽  
Mucinous Epithelium ◽  
Missed Diagnosis ◽  
Cervical Conization

Abstract Background: adenocarcinoma in situ(AIS) cells are often misdiagnosed, and recognizing AIS in cervical cytology is challenging. Here, we present a case of extraperitoneal metastasis 5 years after a missed diagnosis of AIS.Case presentation: We report a 49-year-old Chinese woman who presented with a retroperitoneal mass 5 years after cervical conization for AIS. The retroperitoneal mass was composed of glands lined by malignant mucinous epithelium; these tumors were metastases from her previous AIS which were misdiagonised cervical intraepithelial neoplasia(CIN) III in 2013. The patient is alive and well 2 years after resection of the tumors.Conclusions: An experienced pathologist or multiple pathologists should take part in endocervical AIS diagnosis. We should follow these patients for over 15 years. When Cancer Antigen 125(CA125) or Carcinoembryonic antigen(CEA) levels are elevated, the occurrence of metastases should be strictly monitored.

Cervical conization of adenocarcinoma in-situ: A predicting model of residual disease

2011 ◽  
Vol 123 (2) ◽  
pp. 429-430
Author(s):  
K.E. Tierney ◽  
P.S. Lin ◽  
C. Amezcua ◽  
K. Matsuo ◽  
Y. Wei ◽  
...  
Keyword(s):  
Residual Disease ◽  
Adenocarcinoma In Situ ◽  
Predicting Model ◽  
Cervical Conization

Predictive value of negative cone margin status for risk of residual disease among women with cervical adenocarcinoma in situ

2012 ◽  
Vol 119 (3) ◽  
pp. 266-269 ◽  
Author(s):  
Chumnan Kietpeerakool ◽  
Surapan Khunamornpong ◽  
Jatupol Srisomboon ◽  
Ajchara Kasunan ◽  
Narisa Sribanditmongkol ◽  
...  
Keyword(s):  
Predictive Value ◽  
Residual Disease ◽  
Margin Status ◽  
Cervical Adenocarcinoma ◽  
Adenocarcinoma In Situ

Cervical adenocarcinoma in situ: the predictive value of conization margin status

2007 ◽  
Vol 197 (2) ◽  
pp. 195.e1-195.e8 ◽  
Author(s):  
Jennifer L. Young ◽  
Amir A. Jazaeri ◽  
Jason A. Lachance ◽  
Mark H. Stoler ◽  
William P. Irvin ◽  
...  
Keyword(s):  
Predictive Value ◽  
Margin Status ◽  
Cervical Adenocarcinoma ◽  
Adenocarcinoma In Situ

scholarly journals Adenocarcinoma in situ of the Cervix – is Loop Electrosurgical Excision Procedure an Acceptable Alternative to Cold Knife Cone Biopsy?

2017 ◽  
Vol 13 (01) ◽  
pp. 24
Author(s):  
Mila Pontremoli Salcedo ◽  
Anthony Costales ◽  
Mark F Munsell ◽  
Preetha Ramalingam ◽  
Ricardo Dos Reis ◽  
...  
Keyword(s):  
Specimen Size ◽  
Margin Status ◽  
Adenocarcinoma In Situ ◽  
Median Length ◽  
Positive Margins ◽  
Specimen Volume ◽  
Cold Knife ◽  
Loop Electrosurgical Excision ◽  
Loop Electrosurgical Excision Procedure

Objective: To compare cone specimen size between loop electrosurgical excision procedure (LEEP) and cold knife cone (CKC), and evaluate the association between specimen size and margin status. Methods/materials: A retrospective review was performed of women with adenocarcinoma in situ (AIS) who underwent CKC or LEEP between 1998 and 2013. Specimen size, including length (distance from the external cervical os to the endocervical margin) and volume were compared between LEEP and CKC, and correlated with margin status. Results: Eighty-five patients underwent a total of 136 procedures, including 91 CKCs (67%) and 45 LEEPs (33%), with 27 removed as a single specimen (one-piece LEEP) and 18 as two specimens with an ectocervical specimen and a deeper endocervical top-hat specimen (two-piece LEEP). The two-piece LEEP specimen median length was significantly longer (2.1 cm) versus CKC (1.4 cm, p<0.01) and one-piece LEEP (0.6 cm, p<0.01). Median specimen volume was greater for two-piece LEEP (7.4 cm3) versus CKC (3.4 cm3, p<0.01) and one-piece LEEP (1.6 cm3, p<0.01). A higher rate of positive margins was noted when comparing all LEEP (67.6%) with CKC specimens (34.2%), p<0.01. However, when the LEEP specimens were analysed separately, one-piece LEEPs had a higher rate of positive margins (81.0%) versus CKC (34.2%) (p<0.01), but there were no significant differences between two-piece LEEP (50.0%) and CKC (34.2%), p=0.26. Conclusion: Our results suggest that a two-piece LEEP produces a larger specimen size with similar rates of positive margins compared with CKC. Given the decreased cost and morbidity compared with CKC, a two-piece LEEP should be considered in the management of women with AIS.

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