scholarly journals Case Report About Extraperitoneal Metastasis of Cervical Adenocarcinoma In Situ

2021 ◽  
Author(s):  
Aiwen Le ◽  
Lirong Han ◽  
Peng Wang ◽  
Kai Kang
Keyword(s):  
Intraepithelial Neoplasia ◽  
Adenocarcinoma In Situ ◽  
Retroperitoneal Mass ◽  
Cancer Antigen 125 ◽  
Case Presentation ◽  
Cin Iii ◽  
Mucinous Epithelium ◽  
Missed Diagnosis ◽  
Cervical Conization

Abstract Background: adenocarcinoma in situ(AIS) cells are often misdiagnosed, and recognizing AIS in cervical cytology is challenging. Here, we present a case of extraperitoneal metastasis 5 years after a missed diagnosis of AIS.Case presentation: We report a 49-year-old Chinese woman who presented with a retroperitoneal mass 5 years after cervical conization for AIS. The retroperitoneal mass was composed of glands lined by malignant mucinous epithelium; these tumors were metastases from her previous AIS which were misdiagonised cervical intraepithelial neoplasia(CIN) III in 2013. The patient is alive and well 2 years after resection of the tumors.Conclusions: An experienced pathologist or multiple pathologists should take part in endocervical AIS diagnosis. We should follow these patients for over 15 years. When Cancer Antigen 125(CA125) or Carcinoembryonic antigen(CEA) levels are elevated, the occurrence of metastases should be strictly monitored.

Margin status post cervical conization predicts residual adenocarcinoma in situ and occult adenocarcinoma

2021 ◽  
Vol 162 ◽  
pp. S203-S204
Author(s):  
Linda Hong ◽  
Sandy Huynh ◽  
Joy Kim ◽  
Laura Denham ◽  
Yevgeniya Ioffe
Keyword(s):  
Margin Status ◽  
Adenocarcinoma In Situ ◽  
Cervical Conization

scholarly journals Loop Electrosurgical Excision Procedure in Cervical Intraepithelial Neoplasia

2016 ◽  
Vol 11 (1) ◽  
pp. 58-61
Author(s):  
Rima Maharjan ◽  
BK Thapa ◽  
Neershobha Chitrakar ◽  
Jitendra Pariyar ◽  
Isha Shrestha ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Simple Procedure ◽  
Pap Test ◽  
Intraepithelial Neoplasia ◽  
Final Diagnosis ◽  
Invasive Squamous Cell Carcinoma ◽  
Adenocarcinoma In Situ ◽  
Cervical Lesions

Aims: To evaluate the treatment outcome and acceptance of LEEP in precancerous cervical lesions.Methods: This is a descriptive study performed in Gynecology Department of Civil Service Hospital, from August 2014 - December 2015 in 28 cases that underwent LEEP forCIN. LEEP was performed as day care procedure under intravenous anesthesia and patient was sent home six hours after procedure. Follow up and further treatment was done after final histopathological reports.Results: Highest percentage ofCIN, 32.14% (9) was seen among 30-39 years age with 16 (57.14%) of parity three and more. 17 (60.71%) presented clinic with symptoms (lower abdominal, backpain, pervaginal discharge) while 11 (39.28%) were diagnosed from routine Pap test. Histopathology revealed four (14.28%)CIN1, eight (28.57%)CIN2, 11(39.28%)CIN3, two adenocarcinoma in situ, one of invasive squamous cell carcinoma, chronic cervicitis and atrophic change with no dysplasia. Margins were negative (satisfactory) in 20 (71.42%) and positive in eight (28.57%) with endocervical involvement in two that required second LEEP while one underwent radical hysterectomy for final diagnosis of invasive squamous cell carcinoma.Conclusions: Hysterectomy is a radical procedure for preinvasive cervical lesions that can be treated with simple procedure like LEEP that saves time and financial resources.

scholarly journals Histopathological Diagnosis of Colposcopically Negative Cases for CIN

2020 ◽  
Vol 6 (1) ◽  
pp. 29-32
Author(s):  
Khurshida Samad ◽  
AJE Nahar Rahman ◽  
Imtiaz Ahmed ◽  
Abu Sayeed Mohammad ◽  
Md Sirajul Islam
Keyword(s):  
Precancerous Lesion ◽  
Intraepithelial Neoplasia ◽  
Cross Sectional Study ◽  
Diagnostic Tools ◽  
Histopathological Diagnosis ◽  
Cross Sectional ◽  
Cin Iii ◽  
Medical University ◽  
Chronic Cervicitis

Background: Colposcopy is a good diagnostic tools for the detection of abnormalities cervix of the uterus. Objective: The purpose of the present study was to see the histological diagnosis of colposcopically negative cases for CIN among VIA positive women. Methodology: This cross sectional study was conducted in the Department Of Pathology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July 2007 to June 2008 for one (01) year. Patients who are colposcopically negative but clinically suspicious for cervical neoplasia were included in this study. The cervix was examined on naked eye by Cusco’s speculum to see whether it was healthy or not. Then it was examined by the colposcope after applying 3 to 5% acetic acid and colposcopic findings were collected. VIA positive cases were underwent colposcopy guided LEEP biopsy. Result: A total of 63 patients of different age group were recruited for this study. The age of 63 patients ranged from 20 years to 65 years with an average age of 34.6±9.59 years. Among 63 VIA positive patients, 54 cases were colposcopically positive for cervical intraepithelial neoplasia and carcinoma in situ, remaining 9 patients were colposcopically negative. Histological examination was also performed in nine patients who were colposcopically negative but clinically suspicious for malignancy or precancerous lesion. Of these nine cases, eight cases (89%) were diagnosed as chronic cervicitis, one case (11.0%) as CIN-I and none as CIN-II and CIN- III. Conclusion: In conclusion majority of the colposcopically negative VIA positive cases are the patients of chronic cervicitis. Journal of National Institute of Neurosciences Bangladesh, 2020;6(1): 29-32

scholarly journals The extra 1.5 cm makes the differences: reduced incidence of vaginal intraepithelial neoplasia after modified hysterectomy for CIN3/adenocarcinoma in situ (AIS) patients

2021 ◽  
Author(s):  
Lei Li ◽  
Xiaoyan Song ◽  
Xiaojie Feng ◽  
Xiaofeng Li ◽  
Zhenzhong Zhang ◽  
...  
Keyword(s):  
Blood Loss ◽  
Hospital Stay ◽  
Operative Time ◽  
Disease Free Survival ◽  
Intraepithelial Neoplasia ◽  
Postoperative Recurrence ◽  
Adenocarcinoma In Situ ◽  
Stay Time

Abstract Objectives To assess whether modified hysterectomy can improve locoregional control compared to the standard extrafascial hysterectomy for cervical high grade intraepithelial neoplasia 3 (CIN3)/adenocarcinoma in situ (AIS) patients. Methods A total of 135 CIN3/AIS patients from May 2014 to March 2018 were enrolled and randomized to different hysterectomy group and finally 128 patients were eligible for analysis, in which 60 patients received standard extrafascial hysterectomy and 68 patients received modified hysterectomy by removing extra 1.5cm of vagina. Intra-operative variables including operative time, estimated amount of blood loss, urinary catheter time, hospital stay time and postoperative complications, most importantly the postoperative recurrence and disease free survival (DFS) were compared and analyzed. Results Age, BMI and histology grade were comparable between these two groups. No significant differences were found at median surgical times, blood loss and postoperative hospital stay neither laparoscopicly nor abdominally, and neither was found about the incidences of fistulas, or other surgical complications. No incidences of prolonged urinary retention were found in both groups. With a median follow-up of 47.3 months (range 11–64 months), the modified hysterectomy group and had a significantly improved in DFS rate compared to the standard extrafascial hysterectomy group (P = 0.026). No disease related death occurred in the follow-up time. Conclusion With similar intra-operative variables operative time, modified hysterectomy appeared to provide the most reliable specimens and significantly reduced the postoperative vaginal recurrence rate for CIN3/AIS patients who choose remove their uterus when compared with standard extrafascial hysterectomy.

scholarly journals HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples

2020 ◽  
Author(s):  
Sonja Lagström ◽  
Alexander Hesselberg Løvestad ◽  
Sinan Uğur Umu ◽  
Ole Herman Ambur ◽  
Mari Nygård ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Progressive Disease ◽  
Intraepithelial Neoplasia ◽  
Adenocarcinoma In Situ ◽  
Coding Region ◽  
Human Papillomavirus 16 ◽  
Diagnostic Categories ◽  
Cervical Cell ◽  
Lesion Severity

AbstractHuman papillomavirus 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that genomic factors, such as minor nucleotide variation caused by APOBEC3 and chromosomal integration, contribute to the carcinogenesis.We analysed minor nucleotide variants (MNVs) and integration in HPV16 and HPV18 positive cervical samples with different morphology. Samples were sequenced using an HPV whole genome sequencing protocol TaME-seq. A total of 80 HPV16 and 51 HPV18 positive cervical cell samples passed the sequencing depth criteria of 300× reads, showing the following distribution: non-progressive disease (HPV16 n=21, HPV18 n=12); cervical intraepithelial neoplasia (CIN) grade 2 (HPV16 n=27, HPV18 n=9); CIN3/adenocarcinoma in situ (AIS) (HPV16 n=27, HPV18 n=30); cervical cancer (HPV16 n=5).Similar rates of MNVs in HPV16 and HPV18 samples were observed for most viral genes but for HPV16, the non-coding region (NCR) showed a trend towards increasing variation with increasing lesion severity. APOBEC3 signatures were observed in HPV16 lesions, while similar mutation patterns were not detected for HPV18. The proportion of samples with integration was 13% for HPV16 and 59% for HPV18 positive samples, with a noticeable portion located within or close to cancer-related genes.

scholarly journals Loop electrosurgical excision procedure combined with cold coagulation for cervical intraepithelial neoplasia and adenocarcinoma in-situ: A feasible treatment with a low risk of residual/recurrent disease

2020 ◽  
Author(s):  
Eun Jung Yang ◽  
Nae Ry Kim ◽  
Ji Yeon Choi ◽  
Wook Youn Kim ◽  
Sun Joo Lee
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Additional Treatment ◽  
Definitive Treatment ◽  
Resection Margins ◽  
Adenocarcinoma In Situ ◽  
Loop Electrosurgical Excision ◽  
Cold Coagulation ◽  
Loop Electrosurgical Excision Procedure

Abstract Objective This study was performed to evaluate the significance of positive resection margins (RMs) with the loop electrosurgical excision procedure combined with cold coagulation (LEEP with CC) as a definitive treatment for patients with cervical intraepithelial neoplasia (CIN) and adenocarcinoma in-situ . Methods We retrospectively reviewed 467 patients who underwent LEEP with CC. A right-angled triangular loop in a single pass followed by a CC (120°C) to the cone bed for 10 to 20 seconds was used. Pathology reports and clinical data were obtained and evaluated. Results Histopathology evaluation of LEEP tissue samples revealed the presence of CIN 1 in 69, CIN 2/3 in 366, AIS in 5 and invasive carcinoma in 16 (microinvasive squamous cell carcinoma (SCC) and invasive SCC, 13 and 3) patients. Margins were positive in 66 (14.5%) cases: 0 in CIN 1, 54 in CIN 2/3 (12.4%), 1 in AIS (20.0%) and 11 in microinvasive/invasive SCC (68.8%). Although 54 CIN2/3 patients with positive RMs did not undergo additional treatment, 1 of these (1.9%) was confirmed to have residual CIN3 at the first follow-up. Two of 8 (25.0%) microinvasive SCC patients with positive RMs were confirmed to have residual diseases (1 microinvasive SCC and 1 invasive SCC) after hysterectomy. Four out of 360 (1 positive RM, 3 negative RM) CIN cases recurred during the study period. Conclusions These results suggest that CIN patients with positive RMs after LEEP with CC may be followed up without additional treatment.

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