Role of IgE mediated food hypersensitivity in the pathogenesis of atopic dermatitis

1982 ◽  
Vol 69 (1) ◽  
pp. 109
Author(s):  
H.A. Sampson
1988 ◽  
Vol 81 (1) ◽  
pp. 186
Author(s):  
A.W. Burks ◽  
M.A. Sherrill ◽  
S.B. Mallory ◽  
L.W. Williams

2021 ◽  
Vol 22 (13) ◽  
pp. 7227
Author(s):  
Lai-San Wong ◽  
Yu-Ta Yen ◽  
Chih-Hung Lee

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.


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