Faculty Opinions recommendation of Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment.

2008 ◽  
Author(s):  
Peter Schmid-Grendelmeier
Keyword(s):  
Atopic Dermatitis ◽  
Epidermal Barrier

INFLUENCE OF BACTRIO-CARRY IN THE FAMILY ON THE COURSE OF ATOPIC DERMATITIS IN A CHILD

2021 ◽  
pp. 114-119
Author(s):  
Vasileva E.A. ◽  
Kuyarov A.A. ◽  
Kuyarov A.V.
Keyword(s):  
Atopic Dermatitis ◽  
Secondary Infection ◽  
Family Members ◽  
Upper Respiratory Tract ◽  
Epidermal Barrier ◽  
The Family ◽  
Mucous Membranes ◽  
High Degree ◽  
Nose And Throat

The pathogenesis of atopic dermatitis (AD) is complex, and at present a unified concept of the development of the disease has not been formed. At the heart of pathogenesis, there is a complex interaction of numerous factors, such as genetic predisposition, dysfunction of the autonomic nervous system and the epidermal barrier. Previously, it has been proven that a high microbial contamination of the affected areas helps to maintain inflammation and aggravates skin dysfunction as a result of chronic inflammation, and favorable factors appear for the attachment of a secondary infection. However, little attention has been paid to dysfunctions of the epidermal barrier, the role of violations of the quantitative and qualitative composition of the microbiota in the development of AD, and this issue remains relevant at the present time. The aim of this study was to assess the effect of the carrier of bacteria on the mucous membranes of the upper respiratory tract in family members on the course of atopic dermatitis in a child. A bacteriological examination of the mucous membranes of the nose and throat was carried out in 34 children with AD and members of their families (74 people). When examining the mucous membranes of the nose and throat in family members of children with AD, it was found that the microflora isolated from family members in more than half of the cases has an increased potential for pathogenicity with a high degree of contamination (CFU lg 3), which forms an increased bacteriological load on the child. The tendency of bacterial carriage was revealed, contributing to the formation in the family of a permanent persistence of microflora with a high potential for pathogenicity. Asymptomatic carriage of bacteria forms an additional epidemiological load on the child, affects the severity of AD and is a risk factor in the development of secondary infection of the skin.

Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment

Allergy ◽  
2008 ◽  
Vol 63 (2) ◽  
pp. 205-210 ◽  
Author(s):  
F. Boralevi ◽  
T. Hubiche ◽  
C. Léauté-Labrèze ◽  
E. Saubusse ◽  
M. Fayon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Epidermal Barrier

scholarly journals THE ROLE OF EPIDERMAL BARRIER IMPAIRMENTS IN ATOPIC DERMATITIS: MODERN CONCEPTS OF DISEASE PATHOGENESIS

2018 ◽  
Vol 17 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Nikolay N. Murashkin ◽  
Eduard T. Ambarchian ◽  
Alexander I. Materikin ◽  
Roman V. Epishev
Keyword(s):  
Atopic Dermatitis ◽  
Disease Pathogenesis ◽  
Epidermal Barrier ◽  
Concepts Of Disease

scholarly journals The correction of epidermal barrier dysfunction in atopic dermatitis patients

2016 ◽  
Vol 13 (3) ◽  
pp. 59-64
Author(s):  
O G Elisyutina ◽  
O V Shtyrbul ◽  
E N Zemskaya
Keyword(s):  
Atopic Dermatitis ◽  
Genetic Disorders ◽  
Multifactorial Disease ◽  
Complex Treatment ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Endogenous Factors ◽  
Leading Role ◽  
Mechanisms Of Development

Atopic dermatitis is chronic inflammatory multifactorial disease, which has genetic disorders, immune mechanisms of development and is under the ainfluence of a combination of exogenous and endogenous factors. Recently a leading role of the epidermal barrier dysfunction in the pathogenesis of atopic dermatitis was shown. The article presents data about emollient for skin care efficacy - Cetaphil® RESTORADERM, which consists of preceramides and filaggrin breakdown products in complex treatment of atopic dermatitis patients.

scholarly journals Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis

2020 ◽  
Vol 17 (4) ◽  
pp. 334-339
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchyan ◽  
Roman V. Epishev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Main Role ◽  
Social Maladjustment ◽  
Active Components ◽  
Epidermal Barrier ◽  
New Class

Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.

scholarly journals Epidermal Hyaluronan in Barrier Alteration-Related Disease

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3096
Author(s):  
Céline Evrard ◽  
Catherine Lambert de Rouvroit ◽  
Yves Poumay
Keyword(s):  
Atopic Dermatitis ◽  
Normal Skin ◽  
Intercellular Spaces ◽  
Epidermal Barrier ◽  
Keratinocyte Proliferation ◽  
Lesional Skin ◽  
Related Disease ◽  
Sulfated Glycosaminoglycan ◽  
Proliferation And Differentiation

In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism.

Role of the epidermal barrier in atopic dermatitis

2009 ◽  
Vol 7 (10) ◽  
pp. 899-910 ◽  
Author(s):  
Ehrhardt Proksch ◽  
Regina Fölster-Holst ◽  
Matthias Bräutigam ◽  
Marjan Sepehrmanesh ◽  
Stephan Pfeiffer ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Epidermal Barrier

scholarly journals Role of skin microbiome in epidermal barrier dysfunction and development of atopic dermatitis in high risk infants

2019 ◽  
Vol 16 (1) ◽  
pp. 59-64
Author(s):  
N B Migacheva
Keyword(s):  
At Risk ◽  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Microbiome ◽  
Children At Risk ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Microbiome Composition

Background. Colonization of skin with S. aureus in atopic dermatitis (AD) patients is a widespread phenomenon and a factor complicating the course of the disease. At present, it is not quite clear the role of S. aureus in the development of AD in children at risk. The aim of our study was to discribe the skin microbiome composition in young children at risk, as well as to investigate the role of S. aureus in skin barrier dysfunction and the development of AD. Material and methods. 12months follow-up study of 37 infants at risk has been performed. It included a general clinical examination, a microbiological investigation of skin microbiome (at 1 and 6 months), and investigation of epidermal barrier function by determining the transepidermal water loss (TEWL) at 1, 3, 6 and 12 months. Realization of AD during the observation period was considered as main outcome. Results. The prevalence of S. aureus colonization of infants aged 1 month was 45.9%, at the age of 6 months - 29.7%. Correlation analysis revealed an association between the skin colonization with S. aureus and a decrease of TEWL (p = 0.004), as well as the cumulative incidence of AD (p

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