THE ROLE OF PATCH TESTING FOR FOOD ADDITIVES IN CHILDREN WITH ATOPIC DERMATITIS

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

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Staphylococcal Communities on Skin Are Associated with Atopic Dermatitis and Disease Severity

Microorganisms ◽

10.3390/microorganisms9020432 ◽

2021 ◽

Vol 9 (2) ◽

pp. 432

Author(s):

Sofie Marie Edslev ◽

Caroline Meyer Olesen ◽

Line Brok Nørreslet ◽

Anna Cäcilia Ingham ◽

Søren Iversen ◽

...

Keyword(s):

Atopic Dermatitis ◽

Alpha Diversity ◽

Skin Microbiota ◽

Specific Primers ◽

Staphylococcus Lugdunensis ◽

Disease Symptoms ◽

Lesional Skin ◽

Staphylococcus Capitis ◽

Staphylococcus Hominis

The skin microbiota of atopic dermatitis (AD) patients is characterized by increased Staphylococcus aureus colonization, which exacerbates disease symptoms and has been linked to reduced bacterial diversity. Skin bacterial communities in AD patients have mostly been described at family and genus levels, while species-level characterization has been limited. In this study, we investigated the role of the bacteria belonging to the Staphylococcus genus using targeted sequencing of the tuf gene with genus-specific primers. We compared staphylococcal communities on lesional and non-lesional skin of AD patients, as well as AD patients with healthy controls, and determined the absolute abundance of bacteria present at each site. We observed that the staphylococcal community, bacterial alpha diversity, and bacterial densities were similar on lesional and non-lesional skin, whereas AD severity was associated with significant changes in staphylococcal composition. Increased S. aureus, Staphylococcus capitis, and Staphylococcus lugdunensis abundances were correlated with increased severity. Conversely, Staphylococcus hominis abundance was negatively correlated with severity. Furthermore, S. hominis relative abundance was reduced on AD skin compared to healthy skin. In conclusion, various staphylococcal species appear to be important for skin health.

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Role of Natural Killer T-Cells in a Murine Model of Atopic Dermatitis (AD)

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.12.925 ◽

2006 ◽

Vol 117 (2) ◽

pp. S234

Author(s):

A. Elkhal ◽

M. Pichavant ◽

R. Geha ◽

D. Umetsu

Keyword(s):

T Cells ◽

Atopic Dermatitis ◽

Natural Killer ◽

Murine Model ◽

Natural Killer T Cells ◽

Killer T Cells ◽

Natural Killer T

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The role of patch testing in the management of oral lichenoid reactions

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12328 ◽

2015 ◽

Vol 45 (1) ◽

pp. 48-57 ◽

Cited By ~ 26

Author(s):

Valerie G. A. Suter ◽

Saman Warnakulasuriya

Keyword(s):

Patch Testing ◽

Lichenoid Reactions

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