Allergen immunotherapy: Therapeutic vaccines for allergic diseases A WHO position paper☆☆☆★★★♢

In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of allergic diseases. However, current allergen immunotherapy shows limitations concerning the long-term efficacy and safety due to local side effects and risk of anaphylaxis. Thus, effective and safe vaccines with reduced dose of allergen have been developed using adjuvants. Nevertheless, the use of adjuvants still has several disadvantages, which limits its use in human vaccines. In this context, several novel adjuvants for allergen immunotherapy are currently being investigated and developed. Currently, nanoparticles-based allergen-delivery systems have received much interest as potential adjuvants for allergen immunotherapy. It has been demonstrated that the incorporation of allergens into a delivery system plays an important role in the efficacy of allergy vaccines. Several nanoparticles-based delivery systems have been described, including biodegradable and nondegradable polymeric carriers. Therefore, this paper provides an overview of the current adjuvants used for allergen immunotherapy. Furthermore, nanoparticles-based allergen-delivery systems are focused as a novel and promising strategy for allergy vaccines.

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Placebo effects in allergen immunotherapy – an EAACI Task Force Position Paper

Allergy ◽

10.1111/all.14331 ◽

2020 ◽

Cited By ~ 6

Author(s):

O Pfaar ◽

I Agache ◽

KC Bergmann ◽

C Bindslev‐Jensen ◽

J Bousquet ◽

...

Keyword(s):

Allergen Immunotherapy ◽

Task Force ◽

Position Paper ◽

Placebo Effects

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Position paper on the specific allergen immunotherapy. Part 3

Alergologia Polska - Polish Journal of Allergology ◽

10.5114/pja.2018.80742 ◽

2018 ◽

Vol 5 (4) ◽

pp. 173-174

Author(s):

Marek Jutel ◽

Ewa Cichocka-Jarosz ◽

Maciej Kupczyk

Keyword(s):

Allergen Immunotherapy ◽

Position Paper ◽

Specific Allergen

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Impact of Tree Pollen Distribution on Allergic Diseases in Serbia: Evidence of Implementation of Allergen Immunotherapy to Betula verrucosa

Medicina ◽

10.3390/medicina56020059 ◽

2020 ◽

Vol 56 (2) ◽

pp. 59 ◽

Cited By ~ 1

Author(s):

Rajna Minić ◽

Mirjana Josipović ◽

Vesna Tomić Spirić ◽

Marija Gavrović-Jankulović ◽

Aleksandra Perić Popadić ◽

...

Keyword(s):

Allergen Immunotherapy ◽

Practical Importance ◽

Allergic Diseases ◽

Pollen Concentration ◽

Tree Pollen ◽

Starting Point ◽

Pollen Species ◽

Allergenic Plants ◽

Betula Verrucosa ◽

The Relationship

Background and objectives: The relationship between air pollen quantity and the sensitization of allergic patients is crucial for both the diagnosis and treatment of allergic diseases. Weather conditions influence the distribution of allergenic pollen and increases in pollen concentration may negatively affect the health of allergic patients. The aim of this study was to analyze the implementation of allergen immunotherapy with regard to air pollen concentration. Material and Methods: Here we examined the relationship between Betula air pollen concentration and the usage of Betula verrucosa allergen immunotherapy in Serbia. Examination covered the period from 2015 to 2018. Measurement of airborne pollen concentration was performed with Lanzoni volumetric pollen traps. The evidence of the usage of sublingual allergen immunotherapy (SLIT) was gathered from patients with documented sensitization to specific pollen. Results: During this period tree pollens were represented with 58% ± 21% of all measured air pollen species, while Betula pollen represented 15% ± 8% of all tree pollens. Betula pollination peaked in April. Allergen immunotherapy to Betula verrucosa in Serbia is entirely conducted as sublingual immunotherapy and represents 47.1% ± 1.4% of issued tree pollen SLIT. The use of pollen SLIT increased by 68% from 2015 to 2018, with an even greater increase in usage recorded for Betula SLIT—80%. Conclusions: This analysis shows a clear causative relationship between pollination and the type/prevalence of applied allergen immunotherapy. Information about the flowering seasons of allergenic plants is very important for people who suffer from allergy, for clinical allergologists, as well as for governing authorities. The presented data is of practical importance to the proper timing of immunotherapy initiation and of importance for urban landscaping. The obtained data can be the starting point for the instatement of a thorough epidemiological study and the inclusion of Serbia on the pollen map of Europe.

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