Blood Component Transfusion Audit: A Comprehensive Microcomputer Program

Abstract Context.—Serious noninfectious complications are far more likely to occur than viral disease transmission from blood component transfusion. Objective.—To compile a comprehensive list of the noninfectious risks of transfusion, examples of published risk estimates, and summaries of recent information regarding cause, prevention, or management of noninfectious transfusion risks. Data Sources.—Information was obtained from peer-reviewed English-language medical journal publications since 1990. Conclusions.—Early complications, although potentially more serious, usually occur less frequently (<1 in 1000 transfusions) than late complications, which often affect more than 1% of recipients. Areas of active investigation and discussion include acute hemolytic reactions, transfusion-related acute lung injury, red cell alloimmunization, platelet transfusion refractoriness, and transfusion immunosuppression. Continued effort toward research and education to promote recognition and prevention of noninfectious complications associated with blood components is warranted.

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Blood Component Transfusion Guidelines for Transfusing Physicians

Handbook of Blood Banking and Transfusion Medicine ◽

10.5005/jp/books/10339_11 ◽

2006 ◽

pp. 133-133

Author(s):

Ted Eastlund ◽

Kathrine Frey ◽

David Mair

Keyword(s):

Blood Component ◽

Blood Component Transfusion ◽

Transfusion Guidelines

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Blood and Blood Component Transfusion

Principles and Practice of Obstetrics and Gynecology for Postgraduates ◽

10.5005/jp/books/10673_44 ◽

2008 ◽

pp. 1240-1240

Author(s):

Rahul Wani

Keyword(s):

Blood Component ◽

Blood Component Transfusion

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Quantification of thrombelastographic changes after blood component transfusion in patients with liver disease

Hepatology ◽

10.1016/0270-9139(93)90422-j ◽

1993 ◽

Vol 18 (3) ◽

pp. 741

Author(s):

D Clayton

Keyword(s):

Liver Disease ◽

Blood Component ◽

Blood Component Transfusion

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From Donor to Recipient: Considerations for Blood Transfusion Outcomes Research

Biological Research For Nursing ◽

10.1177/1099800417716542 ◽

2017 ◽

Vol 19 (5) ◽

pp. 491-498

Author(s):

Allison R. Jones ◽

Michelle R. Brown ◽

David E. Vance

Keyword(s):

Patient Care ◽

Patient Outcomes ◽

Outcomes Research ◽

Current Evidence ◽

Patient Specific ◽

Blood Component ◽

Blood Components ◽

Packed Red Blood Cells ◽

Blood Component Transfusion ◽

Donor Characteristics

Donated blood can be broken down into blood components for use in patient care. This article focuses primarily on packed red blood cells (PRBCs), as they experience breakdown during storage that may adversely impact patient outcomes. Patients require PRBC transfusions for a number of clinical reasons. Although transfusions of PRBCs provide some clinical benefit, they are also associated with increased morbidity and mortality across multiple patient populations, albeit the mechanisms underlying this relationship remain unclear. With an aging, more acutely ill population requiring aggressive treatment and a lack of transfusion alternatives, research focused on PRBCs has gained momentum. Proper interpretation of research findings on the part of clinicians depends on accurate data collection that includes aspects of both the transfused blood components and the recipients. The purpose of this article is to examine stored PRBC factors, blood-donor characteristics, transfusion-specific factors, and patient-specific characteristics as they relate to patient outcomes research. Challenges associated with performing and interpreting outcomes of transfusion-related research are presented. Implications of current evidence for patient care, such as awareness of benefits as well as risks associated with blood component transfusion, are also provided.

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