Hypothyroidism to Graves' disease and late appearance of pretibial myxoedema

The Lancet ◽  
2019 ◽  
Vol 394 (10206) ◽  
pp. 1364
Author(s):  
Eveline Bruinstroop ◽  
Irina Cairo ◽  
Paul Drillenburg ◽  
P Sytze van Dam
Keyword(s):  
Graves Disease ◽  
Pretibial Myxoedema

scholarly journals Atypical Presentation of Pretibial Myxoedema in Graves’ Disease

2017 ◽  
Vol 35 (1) ◽  
pp. 46
Author(s):  
Quazi Tarikul Islam ◽  
Abdul Basit Ibne Momen ◽  
Abul Kashem Khondokar ◽  
HAM Nazmul Ahasan ◽  
Homayra Tahseen
Keyword(s):  
Graves Disease ◽  
Atypical Presentation ◽  
Pretibial Myxoedema

Abstract not availableJ Bangladesh Coll Phys Surg 2017; 35(1): 46

Pretibial myxoedema without thyroid associated orbitopathy in a patient with Graves’ disease

2017 ◽  
Vol 94 (1110) ◽  
pp. 236-236
Author(s):  
Sailesh Lodha ◽  
Nimisha Jain ◽  
Anil Bhansali
Keyword(s):  
Graves Disease ◽  
Pretibial Myxoedema

Thyrotrophin receptor antibody characteristics in a woman with long-standing Hashimoto's who developed Graves' disease and pretibial myxoedema

2012 ◽  
Vol 77 (3) ◽  
pp. 465-470 ◽  
Author(s):  
C. Kamath ◽  
S. Young ◽  
K. Kabelis ◽  
J. Sanders ◽  
M. A. Adlan ◽  
...  
Keyword(s):  
Graves Disease ◽  
Receptor Antibody ◽  
Pretibial Myxoedema

LONG ACTING THYROID STIMULATOR (LATS) AND IODO-AMINO ACIDS IN LOCALIZED PRETIBIAL MYXOEDEMA

1968 ◽  
Vol 59 (3) ◽  
pp. 409-416 ◽  
Author(s):  
Sven-Mårten Samuelsson ◽  
Ivar Werner
Keyword(s):  
Amino Acids ◽  
High Titre ◽  
Graves Disease ◽  
Nodular Goitre ◽  
The Third ◽  
Serum Titre ◽  
Long Acting ◽  
Pretibial Myxoedema

ABSTRACT Three patients with so-called localized pretibial myxoedema were studied. The serum titre of LATS activity and the contents of iodo-amino acids were determined. One patient who simultaneously developed a diffuse toxic goitre and pretibial myxoedema showed a high titre of LATS. The second patient who developed pretibial myxoedema showed no LATS activity. This patient probably had a recurrence of Graves' disease in a nodular goitre. The third patient who developed pretibial myxoedema a few years after thyroidectomy for diffuse toxic goitre possibly had a low titre of LATS. The serum contents of iodo-amino acids were increased in cases 1 and 2. The analysis was unsuccessful in case 3. The significance of the findings is briefly discussed. It is concluded that the development of pretibial myxoedema is not correlated with the occurrence of LATS.

CASE REPORT-Delayed Cutaneous Manifestations of Graves’ disease, ADecade Post-Total Thyroidectomy

2020 ◽  
Vol 3 (2) ◽  
pp. 1-4
Keyword(s):  
Case Report ◽  
Total Thyroidectomy ◽  
Lower Limbs ◽  
Graves Disease ◽  
Cutaneous Manifestations ◽  
Digital Clubbing ◽  
Pretibial Myxoedema

Pretibial myxoedema and thyroid acropachy are rare manifestations of Graves’ disease. Clinically, pretibial myxoedema is characterised by hyper-pigmented,asymmetrical, indurated non-pitting lesions of the lower limbs, whilst thyroidacropachy presents as digital clubbing and swelling of digits and toes. We describe a59-year-old female, who presents with pretibial myxoedema and thyroid acropachy,a decade post-thyroidectomy for Graves’ disease.

Treatment of pretibial myxoedema with pentoxifylline

2012 ◽  
Vol 153 (43) ◽  
pp. 1719-1722 ◽  
Author(s):  
Boglárka Türke ◽  
Csaba Balázs
Keyword(s):  
Inhibitory Effect ◽  
Graves Disease ◽  
Histological Studies ◽  
Time Of Admission ◽  
Receptor Antibodies ◽  
Tsh Receptor Antibodies ◽  
Rare Symptom ◽  
Pretibial Myxoedema

Pretibial myxoedema is a rare symptom of Graves’ disease. Histological studies detected mucopolysaccharide and glycosaminoglycan accumulation, and the role of anti-TSH receptor antibodies has been suggested. In this paper the authors present the case of a 34-year-old male patient with pretibial myxoedema treated successfully with pentoxifylline. In his case history multiple autoimmune diseases (type 1 diabetes mellitus, Graves’ disease with severe ophthalmopathy) concomitantly occurred. His severe pretibial myxoedema was undiagnosed and untreated at the time of admission. Because of his diabetes, steroid was contraindicated, which made the choice of the treatment more difficult. He received first intradermal, then intravenous and, finally, oral pentoxifylline, which resulted in a regression of the dermatological symptoms. The beneficial effect of pentoxifylline might be explained by its inhibitory effect of proinflammatory cytokines and proliferation of fibroblasts, and the production of glycosaminoglycan. It was concluded that pentoxifylline can be an effective and safe treatment of pretibial myxoedema. Orv. Hetil., 2012, 153, 1719–1722.

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