Benign hepatic tumors and cysts in women using oral contraceptive agents: computed tomography as a diagnostic aid

1977 ◽  
Vol 1 (3) ◽  
pp. 237
Author(s):  
Stephen I. Schabel
1986 ◽  
Vol 22 (6) ◽  
pp. 984
Author(s):  
H S Yoo ◽  
J T Lee ◽  
J H Suh ◽  
H Y Yune

1973 ◽  
Vol 45 (s1) ◽  
pp. 295s-299s ◽  
Author(s):  
L. R. Krakoff ◽  
M. Mendlowitz

1. Plasma renin activity and plasma renin substrate were measured by radioimmunoassay of generated angiotensin I in patients with steroid excess syndromes. Significant increases in substrate were observed in patients with Cushing's syndrome, during glucocorticoid therapy and on oral contraceptive agents. Suppression of plasma renin activity occurred only in primary aldosteronism. 2. The Michaelis constant (Km) for the reaction between renin and substrate in plasma at physiological pH (7.4) was also determined. The extent to which elevated plasma renin substrate increases the velocity of angiotensin I formation was then calculated. 3. In patients with Cushing's syndrome, glucocorticoid therapy or oral contraceptive use, elevated renin substrate coupled with failure of suppression of circulating renin results in increased angiotensin I formation.


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