Pneumococcal immune complexes and clinical course of secretory otitis media

Infection and inflammation of the middle ear cleft are important factors in the pathogenesis of secretory otitis media. Although high percentages of negative cultures are confronted in many studies, strong evidence pointing to the infectious nature of this disease could not be overlooked. Many authors agree about the failure of conventional culture methods in identifying the responsible pathogen or pathogens. Besides, some agents, such as some kinds of antibiotics, lysozyme, and perhaps some undetected materials, are capable of changing bacterial behavior and consequently the clinical course. Effusions taken from 40 ears with secretory otitis media were cultured by means of conventional brain-heart infusion broth and special hypertonic thioglycollate broth. Strikingly, bacterial L-forms were detected in 6 specimens in thioglycollate broth, with no growth in the conventional broth. We concluded that these atypical forms of bacteria, the L-forms, may play an important role in the bacteriologic aspect of secretory otitis media.

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Immune Complexes in Middle Ear Fluid in Chronic Secretory Otitis Media

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948309200110 ◽

1983 ◽

Vol 92 (1) ◽

pp. 42-44 ◽

Cited By ~ 23

Author(s):

Tauno Palva ◽

Tessa Lehtinen ◽

Juhani Rinne

Keyword(s):

Streptococcus Pneumoniae ◽

Otitis Media ◽

Middle Ear ◽

Immune Complexes ◽

Complex Disease ◽

Capsular Polysaccharide ◽

Immune Complex Disease ◽

Secretory Otitis Media ◽

Opportunistic Bacteria ◽

Middle Ear Fluid

Data on 87 patients (113 ears) with chronic secretory otitis media (SOM) are reported. The bacteriological analysis of the middle ear fluid (MEF) revealed Streptococcus pneumoniae in 7% of ears, Hemophilus influenzae in 9%, opportunistic bacteria in 20%, while 64% of the samples showed no growth. Free capsular polysaccharide pneumococcal antigens were found in 5 % of the MEF samples using counterimmunoelectrophoresis (CIEP) with Omniserum containing 83 different pneumococcal polysaccharide types. Heating of the samples to disrupt the immune complexes increased the frequency of positive samples to 27%. These findings, together with the frequent occurrence of S pneumoniae and H influenzae in the nasopharynx, strongly support the opinion that chronic SOM in a considerable number of cases is an immune complex disease.

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Influence of Adenoid Hypertrophy on Secretory Otitis Media

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948109000103 ◽

1981 ◽

Vol 90 (1) ◽

pp. 7-11 ◽

Cited By ~ 9

Author(s):

Hans H. Elverland ◽

Olav K. Haugeto ◽

Iain W. S. Mair ◽

Knut E. Schrøder

Keyword(s):

Otitis Media ◽

Nasal Obstruction ◽

Clinical Course ◽

Adenoid Hypertrophy ◽

Secretory Otitis Media ◽

Pathogenetic Mechanisms ◽

Tympanostomy Tubes ◽

First Recurrence ◽

Observation Period

The prognostic influence of adenoidectomy on the clinical course of chronic secretory otitis media (SOM) is reported after an observation period of five years in 166 children. Adenoidectomy was performed in connection with the first tubulation on the basis of concurrent symptoms of nasal obstruction, and resulted in a significant reduction in the need for repeated insertion of tympanostomy tubes in patients younger than eight years of age. The tubulation rate was also significantly reduced when adenoidectomy was performed in association with the first recurrence of SOM. This effect was, however, absent when the operation was performed at later stages, and both the otoscopic and audiological findings after five years revealed no significant differences between the adenoidectomy and nonadenoidectomy groups. Possible pathogenetic mechanisms leading to the development of SOM in the presence of large adenoids are discussed.

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Immune Complexes in the Middle Ear Fluid and Adenoid Tissue in Chronic Secretory Otitis Media

Acta Oto-Laryngologica ◽

10.3109/00016488309139439 ◽

1983 ◽

Vol 95 (5-6) ◽

pp. 539-543 ◽

Cited By ~ 21

Author(s):

T. Palva ◽

T. Lehtinen ◽

H. Virtanen

Keyword(s):

Otitis Media ◽

Middle Ear ◽

Immune Complexes ◽

Secretory Otitis Media ◽

Adenoid Tissue ◽

Middle Ear Fluid

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A Case of Primary Secretory Otitis Media in a Cavalier King Charles Spaniel

The Japanese Journal of Veterinary Dermatology ◽

10.2736/jjvd.20.91 ◽

2014 ◽

Vol 20 (2) ◽

pp. 91-95

Author(s):

Takehiro Hasegawa

Keyword(s):

Otitis Media ◽

Secretory Otitis Media ◽

Cavalier King Charles Spaniel

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Otoscopy and tympanometry in the diagnosis of secretory otitis media

Jornal de Pediatria ◽

10.2223/jped.454 ◽

1998 ◽

Vol 74 (5) ◽

pp. 365-7 ◽

Cited By ~ 4

Author(s):

Guilherme L.S. Franche ◽

Letícia M.V. Tabajara ◽

Jaime L.F. Arrarte ◽

Moacyr Saffer

Keyword(s):

Otitis Media ◽

Secretory Otitis Media

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Alteration of adenoid tissue alkaline and acid phosphatase in children with secretory otitis media

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2005.11.002 ◽

2006 ◽

Vol 70 (6) ◽

pp. 1069-1076 ◽

Cited By ~ 1

Author(s):

Snezana Jesic ◽

Ljuba Stojiljkovic ◽

Zeljko Petrovic ◽

Vladimir Djordjevic ◽

Vladimir Nesic ◽

...

Keyword(s):

Acid Phosphatase ◽

Otitis Media ◽

Secretory Otitis Media ◽

Adenoid Tissue ◽

Alkaline And Acid Phosphatase

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Air Conduction Thresholds and Secretory Otitis Media: A Conventional and Extra-High Frequency Audiometric Comparison

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948909801003 ◽

1989 ◽

Vol 98 (10) ◽

pp. 767-771 ◽

Cited By ~ 11

Author(s):

Iain W. S. Mair ◽

Oddbjørn Fjermedal ◽

Einar Laukli

Keyword(s):

Otitis Media ◽

Middle Ear ◽

High Frequency ◽

Pure Tone ◽

Low Frequency ◽

Secretory Otitis Media ◽

Middle Ear Fluid ◽

Ventilation Tubes ◽

Air Conduction

A comparison has been made of air conduction threshold changes up to 1 year after myringotomy, aspiration of middle ear fluid, and insertion of ventilation tubes in ten patients with bilateral and 12 with unilateral secretory otitis media (SOM). Pure tone air conduction thresholds have been analyzed in three frequency groups: Low frequency (LF; 0.25, 0.5, and 1 kHz), high frequency (HF; 2,4, and 8 kHz), and extra-high frequency (EHF; 10, 12, 14, and 16 kHz). In the LF and HF ranges, significant improvement came during the first 24 hours after intubation, while in the EHF range, threshold lowering occurred gradually over the following 2 months. Possible explanations for these findings are discussed.

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