Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency

Clinical Importance ◽

Diagnostic Analysis ◽

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

Journal of Clinical Investigation ◽

10.1172/jci118830 ◽

1996 ◽

Vol 98 (3) ◽

pp. 610-615 ◽

Cited By ~ 237

Author(s):

X Wei ◽

H L McLeod ◽

J McMurrough ◽

F J Gonzalez ◽

P Fernandez-Salguero

Keyword(s):

Molecular Basis ◽

Fluorouracil Toxicity ◽

P-297 Upfront dihydropyrimidine dehydrogenase deficiency detection to secure 5-FU or capecitabine administration: Application to colorectal cancer patients

Annals of Oncology ◽

10.1016/j.annonc.2021.05.351 ◽

2021 ◽

Vol 32 ◽

pp. S198

Author(s):

N. Mkedder ◽

S. Ghomari-Bezzar

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Colorectal Cancer Patients ◽

Reversible Leukoencephalopathy With Stroke-Like Presentation in a Patient With 5-Dihydropyrimidine Dehydrogenase Deficiency Treated With Continuous 5-Fluorouracil Infusion

Clinical Colorectal Cancer ◽

10.1016/j.clcc.2012.01.004 ◽

2012 ◽

Vol 11 (3) ◽

pp. 215-217 ◽

Cited By ~ 5

Author(s):

Jia Li ◽

James J. Lee ◽

Edward Chu ◽

Joachim M. Baehring

Keyword(s):

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

Cancer ◽

10.1002/1097-0142(19910801)68:3<499::aid-cncr2820680309>3.0.co;2-f ◽

1991 ◽

Vol 68 (3) ◽

pp. 499-501 ◽

Cited By ~ 125

Author(s):

Barry E. Harris ◽

John T. Carpenter ◽

Robert B. Diasio

Keyword(s):

Fluorouracil Toxicity ◽

Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2006.21.1.43 ◽

2006 ◽

Vol 21 (1) ◽

pp. 43 ◽

Cited By ~ 8

Author(s):

Jin Ho Baek ◽

Jong Gwang Kim ◽

Shi Nae Kim ◽

Dong Hwan Kim ◽

Sang Kyun Sohn ◽

...

Keyword(s):

Severe Toxicity ◽

Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del ofDPYD

Nucleosides Nucleotides & Nucleic Acids ◽

10.1080/15257771003730227 ◽

2010 ◽

Vol 29 (4-6) ◽

pp. 509-514 ◽

Cited By ~ 3

Author(s):

A. B. P. van Kuilenburg ◽

J. Meijer ◽

G. Gökcay ◽

T. Baykal ◽

M. E. Rubio-Gozalbo ◽

...

Keyword(s):

Genomic Deletion ◽

Dihydropyrimidine Dehydrogenase Deficiency

Encyclopedia of Molecular Mechanisms of Disease ◽

10.1007/978-3-540-29676-8_491 ◽

2009 ◽

pp. 534-535

Author(s):

Dieter Metze ◽

Tam Nguyen ◽

Birgit Haack ◽

Alexander K. C. Leung ◽

Noriko Miyake ◽

...

Keyword(s):

Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism ◽

Dihydropyrimidine Dehydrogenase Deficiency: Biochemical and Genetic Basis

10.1007/978-3-642-84962-6_24 ◽

1993 ◽

pp. 176-182

Author(s):

R. A. De Abreu

Keyword(s):

Genetic Basis ◽

Dihydropyrimidine Dehydrogenase Deficiency

10.1007/springerreference_109343 ◽

2012 ◽

Keyword(s):

Purine and Pyrimidine Metabolism in Man X - Advances in Experimental Medicine and Biology ◽

Dihydropyrimidine Dehydrogenase Deficiency and 5-Fluorouracil Associated Toxicity

10.1007/0-306-46843-3_49 ◽

2002 ◽

pp. 251-255 ◽

Cited By ~ 6

Author(s):

Andre B. P. Van Kuilenburg ◽

Janet Haasjes ◽

Henk Van Lenthe ◽

Lida Zoetekouw ◽

Hans R. Waterham ◽

...

Keyword(s):