GABAc receptor mediated modulation of glutamatergic synaptic transmission to amacrine cells in the mouse retina

2000 ◽  
Vol 38 ◽  
pp. S32
Author(s):  
K Matsui
Keyword(s):  
Synaptic Transmission ◽  
Amacrine Cells ◽  
Mouse Retina ◽  
Glutamatergic Synaptic Transmission ◽  
Gabac Receptor

Citalopram reduces glutamatergic synaptic transmission in the auditory cortex via activation of 5-HT1A receptors

Neuroreport ◽  
2019 ◽  
Vol 30 (18) ◽  
pp. 1316-1322 ◽  
Author(s):  
Víctor Cervantes-Ramírez ◽  
Martha Canto-Bustos ◽  
Diana Aguilar-Magaña ◽  
Elsy Arlene Pérez-Padilla ◽  
José Luis Góngora-Alfaro ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Auditory Cortex ◽  
Glutamatergic Synaptic Transmission

Modulation by Zn2+ of GABA responses in bipolar cells of the mouse retina

2000 ◽  
Vol 17 (2) ◽  
pp. 273-281 ◽  
Author(s):  
M. KANEDA ◽  
B. ANDRÁSFALVY ◽  
A. KANEKO
Keyword(s):  
Axon Terminal ◽  
Inhibitory Action ◽  
Phosphinic Acid ◽  
Amacrine Cells ◽  
Bipolar Cells ◽  
Mouse Retina ◽  
Induced Responses ◽  
Inhibitory Interaction ◽  
Cell Recording ◽  
Recording Conditions

The localization of endogenous Zn2+ in the mouse retina was examined histochemically and the inhibitory action of Zn2+ on GABA-induced responses was studied in bipolar cells isolated from the mouse retina. Accumulation of endogenous Zn2+ was detected in photoreceptors, bipolar, and/or amacrine cells by either the bromopyridylazo-diethylaminophenol method or the dithizone method. Under whole-cell recording conditions, GABA induced a Cl− current in isolated bipolar cells. The current consisted of two components. The first component was inhibited completely by application of 100 μM bicuculline, suggesting that this is a GABAA-receptor mediated current. The second component was inhibited completely by 100 μM 3-aminopropyl-(methyl)-phosphinic acid, suggesting that this is a GABAC-receptor mediated current. GABAC receptors were present at a higher density on the axon terminal than on dendrites. Zn2+ inhibited both GABAA and GABAC receptors. GABAC receptors were more susceptible to Zn2+; the IC50 for the GABAA receptor was 67.4 μM and that for the GABAC receptor was 1.9 μM. These results suggest that Zn2+ modulates the inhibitory interaction between amacrine and bipolar cells, particularly that mediated by the GABAC receptor.

MODULATION BY P2X RECEPTORS OF THE GLUTAMATERGIC SYNAPTIC TRANSMISSION IN RVLM‐PROJECTING NTS NEURONS OF RATS

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Daniela Accorsi‐Mendonca ◽  
Leni GH Bonagamba ◽  
Ricardo Mauricio Leao ◽  
Benedito H Machado
Keyword(s):  
Synaptic Transmission ◽  
P2x Receptors ◽  
Glutamatergic Synaptic Transmission
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