A new agglomerated KSR-592 β-form crystal system for dry powder inhalation formulation to improve inhalation performance in vitro and in vivo

2003 ◽  
Vol 88 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Kazuhiko Ikegami ◽  
Yoshiaki Kawashima ◽  
Hirofumi Takeuchi ◽  
Hiromitsu Yamamoto ◽  
Kazuki Mimura ◽  
...  
Keyword(s):  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Crystal System

scholarly journals In Vitro and In Vivo Performance of Dry Powder Inhalation Formulations: Comparison of Particles Prepared by Thin Film Freezing and Micronization

2014 ◽  
Vol 15 (4) ◽  
pp. 981-993 ◽  
Author(s):  
Yi-Bo Wang ◽  
Alan B. Watts ◽  
Jay I. Peters ◽  
Sha Liu ◽  
Ayesha Batra ◽  
...  
Keyword(s):  
Thin Film ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Thin Film Freezing

scholarly journals Development of an Innovative, Carrier-Based Dry Powder Inhalation Formulation Containing Spray-Dried Meloxicam Potassium to Improve the In Vitro and In Silico Aerodynamic Properties

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 535 ◽  
Author(s):  
Edit Benke ◽  
Árpád Farkas ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
In Silico ◽  
Chronic Obstructive ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Aerodynamic Properties ◽  
Drug Concentrations ◽  
Anti Inflammatory ◽  
New Formulation ◽  
Spray Dried

Most of the marketed dry powder inhalation (DPI) products are traditional, carrier-based formulations with low drug concentrations deposited in the lung. However, due to their advantageous properties, their development has become justified. In our present work, we developed an innovative, carrier-based DPI system, which is an interactive physical blend of a surface-modified carrier and a spray-dried drug with suitable shape and size for pulmonary application. Meloxicam potassium, a nonsteroidal anti-inflammatory drug (NSAID), was used as an active ingredient due to its local anti-inflammatory effect and ability to decrease the progression of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The results of the in vitro and in silico investigations showed high lung deposition in the case of this new formulation, confirming that the interparticle interactions were changed favorably.

scholarly journals Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles

2009 ◽  
Vol 11 (3) ◽  
Author(s):  
Rania O. Salama ◽  
Leigh Ladd ◽  
Hak-Kim Chan ◽  
Daniela Traini ◽  
Paul M. Young
Keyword(s):  
Controlled Release ◽  
Dry Powder Inhalation ◽  
Dry Powder

In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry Powder Inhaler

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Ashwin Jagannath Mali ◽  
Chellampillai Bothiraja ◽  
Ravindra Nandlal Purohit ◽  
Atmaram Pandurang Pawar
Keyword(s):  
Dry Powder Inhaler ◽  
Dry Powder ◽  
Spray Dried

Development and in vitro-in vivo performances of an inhalable indole-3-carboxaldehyde dry powder to target pulmonary inflammation and infection

2021 ◽  
pp. 121004
Author(s):  
Matteo Puccetti ◽  
Larissa Gomes dos Reis ◽  
Marilena Pariano ◽  
Claudio Costantini ◽  
Giorgia Renga ◽  
...  
Keyword(s):  
Pulmonary Inflammation ◽  
Dry Powder

Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance

2015 ◽  
Vol 491 (1-2) ◽  
pp. 231-242 ◽  
Author(s):  
Eva Faulhammer ◽  
Verena Wahl ◽  
Sarah Zellnitz ◽  
Johannes G. Khinast ◽  
Amrit Paudel
Keyword(s):  
Aerodynamic Performance ◽  
Dry Powder Inhalation ◽  
Dry Powder
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