PO433 EFFICACY AND SAFETY OF LUSEOGLIFLOZIN IN YOUNGER AND ELDERLY JAPANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS: ANALYSIS OF POOLED DATA FROM LONG-TERM PHASE 3 TRIALS

2014 ◽  
Vol 106 ◽  
pp. S267
Author(s):  
M. Ubukata ◽  
S. Sakai ◽  
Y. Samukawa ◽  
T. Sasaki ◽  
M. Haneda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Phase 3 ◽  
Pooled Data ◽  
Elderly Japanese ◽  
Elderly Japanese Patients

scholarly journals The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus

2018 ◽  
Vol 46 (12) ◽  
pp. 5117-5126 ◽  
Author(s):  
Toshihiro Higashikawa ◽  
Tomohiko Ito ◽  
Takurou Mizuno ◽  
Keiichirou Ishigami ◽  
Masaru Kohori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients ◽  
Glycated Haemoglobin ◽  
Creatinine Ratio ◽  
Sodium Potassium ◽  
Elderly Japanese ◽  
Elderly Japanese Patients

Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. Results Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. Conclusion This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration.

Efficacy and safety of metformin for treatment of type 2 diabetes in elderly Japanese patients

2010 ◽  
Vol 11 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Hiroyuki Ito ◽  
Yasuhiro Ohno ◽  
Takaaki Yamauchi ◽  
Yumiko Kawabata ◽  
Hiroshi Ikegami
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Elderly Japanese ◽  
Elderly Japanese Patients

scholarly journals Long-term efficacy and safety of canagliflozin in combination with insulin in Japanese patients with type 2 diabetes mellitus

2017 ◽  
Vol 20 (4) ◽  
pp. 812-820 ◽  
Author(s):  
Nobuya Inagaki ◽  
Shin-ichi Harashima ◽  
Kohei Kaku ◽  
Kazuoki Kondo ◽  
Nobuko Maruyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Term Efficacy
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