scholarly journals Safety and efficacy of ipragliflozin in elderly versus non-elderly Japanese patients with type 2 diabetes mellitus: a subgroup analysis of the STELLA-LONG TERM study

2018 ◽  
Vol 19 (4) ◽  
pp. 327-336 ◽  
Author(s):  
Hiroshi Maegawa ◽  
Kazuyuki Tobe ◽  
Hiromi Tabuchi ◽  
Ichiro Nakamura ◽  
Satoshi Uno
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Term Study ◽  
Safety And Efficacy ◽  
Long Term Study ◽  
Elderly Japanese ◽  
Elderly Japanese Patients

scholarly journals The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus

2018 ◽  
Vol 46 (12) ◽  
pp. 5117-5126 ◽  
Author(s):  
Toshihiro Higashikawa ◽  
Tomohiko Ito ◽  
Takurou Mizuno ◽  
Keiichirou Ishigami ◽  
Masaru Kohori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients ◽  
Glycated Haemoglobin ◽  
Creatinine Ratio ◽  
Sodium Potassium ◽  
Elderly Japanese ◽  
Elderly Japanese Patients

Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. Results Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. Conclusion This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration.

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