Early prediction of successful alpha-interferon therapy of chronic hepatitis C by core-IgM antibodies to hepatitis C virus

1994 ◽  
Vol 20 (2) ◽  
pp. 305-306 ◽  
Author(s):  
Nicolaos C. Tassopoulos ◽  
Angelos E. Hatzakis ◽  
George V. Papatheodoridis ◽  
Gerassimos Karvountzis ◽  
Hugo Troonen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Alpha Interferon ◽  
Early Prediction ◽  
Igm Antibodies

Immunoglobulin M antibody to hepatitis C virus during interferon therapy for chronic hepatitis C

1992 ◽  
Vol 103 (4) ◽  
pp. 1285-1289 ◽  
Author(s):  
Juan Antonio Quiroga ◽  
Orencio Bosch ◽  
Raquel Gonzalez ◽  
Eduardo Marriott ◽  
Inmaculada Castillo ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Immunoglobulin M

scholarly journals Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro

2002 ◽  
Vol 76 (16) ◽  
pp. 8189-8199 ◽  
Author(s):  
Valérie Castet ◽  
Chantal Fournier ◽  
Alexandre Soulier ◽  
Rozenn Brillet ◽  
Joliette Coste ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Primary Cultures ◽  
Indirect Evidence ◽  
Human Hepatocytes ◽  
Alpha Interferon ◽  
Healthy Human

ABSTRACT Chronic hepatitis C is a common cause of liver disease, the complications of which include cirrhosis and hepatocellular carcinoma. Treatment of chronic hepatitis C is based on the use of alpha interferon (IFN-α). Recently, indirect evidence based on mathematical modeling of hepatitis C virus (HCV) dynamics during human IFN-α therapy suggested that the major initial effect of IFN-α is to block HCV virion production or release. Here, we used primary cultures of healthy, uninfected human hepatocytes to show that: (i) healthy human hepatocytes can be infected in vitro and support HCV genome replication, (ii) hepatocyte treatment with IFN-α results in expression of IFN-α-induced genes, and (iii) IFN-α inhibits HCV replication in infected human hepatocytes. These results show that IFN-α acts primarily through its nonspecific antiviral effects and suggest that primary cultures of human hepatocytes may provide a good model to study intrinsic HCV resistance to IFN-α.

HLA class II genotypes associated with chronic hepatitis C virus infection and response to alpha-interferon treatment in Poland

2000 ◽  
Vol 20 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Marta Wawrzynowicz-Syczewska ◽  
James A. Underhill ◽  
Michael A. Clare ◽  
Anna Boron-Kaczmarska ◽  
Ian G. McFarlane ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hla Class Ii ◽  
Alpha Interferon ◽  
Interferon Treatment ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus
Sign in / Sign up

Export Citation Format

Share Document