859 DELETION OF FLIP RESULTS IN IMPAIRED LIVER REGENERATION FOLLOWING PARTIAL HEPATECTOMY

2009 ◽  
Vol 50 ◽  
pp. S313
Author(s):  
V. Lowin ◽  
J.M. Schattenberg ◽  
M.F. Sprinzl ◽  
T. Zimmermann ◽  
P.R. Galle ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Impaired Liver

scholarly journals Delayed liver regeneration in mice lacking liver serum response factor

2007 ◽  
Vol 292 (4) ◽  
pp. G996-G1001 ◽  
Author(s):  
M. Ujue Latasa ◽  
Dominique Couton ◽  
Claude Charvet ◽  
Aurélie Lafanechère ◽  
Jacques-Emmanuel Guidotti ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Serum Response Factor ◽  
Early Response ◽  
Mutant Mice ◽  
Response Factor ◽  
Impaired Liver ◽  
Serum Response

Various immediate early genes (IEGs) upregulated during the early process of liver regeneration are transcriptional targets of the serum response factor (SRF). We show here that the expression of SRF is rapidly induced in rodent liver after partial hepatectomy. Because the inactivation of the SRF gene in mice is embryonic lethal, the in vivo role of SRF in liver regeneration after partial hepatectomy was analyzed in mutant mice conditionally deleted for SRF in the liver. We demonstrate that SRF is not an essential factor for liver ontogenesis. However, adult mutant mice show impaired liver regeneration after partial hepatectomy, associated with a blunted upregulation of various SRF target IEGs. In conclusion, our work suggests that SRF is an early response transcription factor that may contribute to the initial phases of liver regeneration through its activation of IEGs.

Impaired liver regeneration after partial hepatectomy in plasminogen deficient mice

2001 ◽  
Vol 15 (1) ◽  
pp. 2-8 ◽  
Author(s):  
M. Tanaka ◽  
K. Okada ◽  
S. Ueshima ◽  
M. Imano ◽  
H. Ohyanagi ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Impaired Liver ◽  
Deficient Mice

Impaired liver regeneration following partial hepatectomy using the Pringle maneuver: Protective effect of mesna

2009 ◽  
Vol 24 (4) ◽  
pp. 623-632 ◽  
Author(s):  
Petros Ypsilantis ◽  
Maria Lambropoulou ◽  
Ioannis Tentes ◽  
Konstantinos Anagnostopoulos ◽  
Christina Tsigalou ◽  
...  
Keyword(s):  
Protective Effect ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Pringle Maneuver ◽  
Impaired Liver

scholarly journals Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1097-1105 ◽  
Author(s):  
Elizabeth P. Newberry ◽  
Susan M. Kennedy ◽  
Yan Xie ◽  
Jianyang Luo ◽  
Susan E. Stanley ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Genetic Models ◽  
Hepatic Triglyceride ◽  
Impaired Liver ◽  
Triglyceride Content

Impaired liver regeneration after partial hepatectomy in db/db mice

2003 ◽  
Vol 54 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Hirofumi Yamauchi ◽  
Koji Uetsuka ◽  
Taro Okada ◽  
Hiroyuki Nakayama ◽  
Kunio Doi
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Impaired Liver

P0937 : Liver steatosis is associated with increased portal pressures and impaired liver regeneration following partial hepatectomy in mice

2015 ◽  
Vol 62 ◽  
pp. S696
Author(s):  
R. Fahrner ◽  
E. Patsenker ◽  
F. Stickel ◽  
F. Rauchfuss ◽  
U. Settmacher ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Liver Steatosis ◽  
Impaired Liver

Impaired liver regeneration in GBA2-deficient mice

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
ER Almajan ◽  
R Sandhoff ◽  
MC Gonzales ◽  
R Büttner ◽  
S Weber ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Impaired Liver ◽  
Deficient Mice
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