Faculty Opinions recommendation of Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.

2007 ◽  
Author(s):  
Stuart Forbes
Keyword(s):  
Bone Marrow ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Oval Cells ◽  
Hepatic Oval Cells

Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration

2007 ◽  
Vol 132 (3) ◽  
pp. 1077-1087 ◽  
Author(s):  
Seh–Hoon Oh ◽  
Rafal P. Witek ◽  
Si–Hyun Bae ◽  
Donghang Zheng ◽  
Youngmi Jung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Oval Cells ◽  
Hepatic Oval Cells

scholarly journals Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice

2002 ◽  
Vol 36 (5) ◽  
pp. 653-659 ◽  
Author(s):  
Hideaki Fujii ◽  
Tetsuro Hirose ◽  
Shoshiro Oe ◽  
Kentaro Yasuchika ◽  
Hisaya Azuma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Bone Marrow Cells ◽  
Marrow Cells

scholarly journals Encapsulated Whole Bone Marrow Cells Improve Survival in Wistar Rats after 90% Partial Hepatectomy

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Carolina Uribe-Cruz ◽  
Carlos Oscar Kieling ◽  
Mónica Luján López ◽  
Alessandro Osvaldt ◽  
Gustavo Ochs de Muñoz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Survival Rate ◽  
Liver Failure ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Bone Marrow Cells ◽  
Apoptotic Cell ◽  
Regeneration Rate ◽  
Encapsulated Cells ◽  
Marrow Cells

Background and Aims. The use of bone marrow cells has been suggested as an alternative treatment for acute liver failure. In this study, we investigate the effect of encapsulated whole bone marrow cells in a liver failure model.Methods. Encapsulated cells or empty capsules were implanted in rats submitted to 90% partial hepatectomy. The survival rate was assessed. Another group was euthanized at 6, 12, 24, 48, and 72 hours after hepatectomy to study expression of cytokines and growth factors.Results. Whole bone marrow group showed a higher than 10 days survival rate compared to empty capsules group. Gene expression related to early phase of liver regeneration at 6 hours after hepatectomy was decreased in encapsulated cells group, whereas genes related to regeneration were increased at 12, 24, and 48 hours. Whole bone marrow group showed lower regeneration rate at 72 hours and higher expression and activity of caspase 3. In contrast, lysosomal-β-glucuronidase activity was elevated in empty capsules group.Conclusions. The results show that encapsulated whole bone marrow cells reduce the expression of genes involved in liver regeneration and increase those responsible for ending hepatocyte division. In addition, these cells favor apoptotic cell death and decrease necrosis, thus increasing survival.

2 Oval Cells, Bone Marrow, and Liver Regeneration

2012 ◽  
Author(s):  
Anna C. Piscaglia ◽  
Antonio Gasbarrini ◽  
Bryon E. Petersen
Keyword(s):  
Bone Marrow ◽  
Liver Regeneration ◽  
Oval Cells

scholarly journals Activation of NF-κB and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration

Hepatology ◽  
2004 ◽  
Vol 39 (2) ◽  
pp. 376-385 ◽  
Author(s):  
Aránzazu Sánchez ◽  
Valentina M. Factor ◽  
Insa S. Schroeder ◽  
Peter Nagy ◽  
Snorri S. Thorgeirsson
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Oval Cells

scholarly journals Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model

2008 ◽  
Vol 29 (2) ◽  
pp. 448-454 ◽  
Author(s):  
Koji Kubota ◽  
Junpei Soeda ◽  
Ryousuke Misawa ◽  
Motohiro Mihara ◽  
Shiro Miwa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rat Model ◽  
Oval Cells ◽  
Hepatic Oval Cells ◽  
Bone Marrow Derived Cells ◽  
Hepatic Tumorigenesis
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