The FXR agonist obeticholic acid decreases matrix metalloproteinase activity via RECK and TIMP modulation in hepatic ischemia/reperfusion injury

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

Metalloproteinase Activity

The Farnesoid-X-Receptor Agonist Obeticholic Acid Further Increases Biliary Excretion of Asymmetric Dimethylarginine during Hepatic Ischemia/Reperfusion Injury

Journal of Hepatology ◽

10.1016/s0168-8278(16)00423-2 ◽

2016 ◽

Vol 64 (2) ◽

pp. S315

Author(s):

L.G. Di Pasqua ◽

C. Berardo ◽

V. Rizzo ◽

L. Adorini ◽

P. Richelmi ◽

...

Keyword(s):

Reperfusion Injury ◽

Biliary Excretion ◽

Receptor Agonist ◽

Asymmetric Dimethylarginine ◽

Ischemia Reperfusion ◽

Farnesoid X Receptor ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

RECK- and TIMP-mediated downregulation of matrix metalloproteinase activity by obeticholic acid in hepatic ischemia/reperfusion

10.1016/j.dld.2019.12.075 ◽

2020 ◽

Vol 52 ◽

pp. e63

Author(s):

L.G. Di Pasqua ◽

G. Palladini ◽

C. Berardo ◽

V. Siciliano ◽

M. Cagna ◽

...

Keyword(s):

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

Metalloproteinase Activity

Matrix Metalloproteinase-12 Cleaves Tenascin-C and Mediates Early Hepatic Ischemia-Reperfusion Injury.

Transplantation Journal ◽

10.1097/00007890-201407151-00138 ◽

2014 ◽

Vol 98 ◽

pp. 41

Author(s):

J. Baber ◽

S. Duarte ◽

H. Kato ◽

R. Busuttil ◽

A. Coito

Keyword(s):

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Hepatic Ischemia ◽

Tenascin C ◽

Matrix Metalloproteinase 12

SAT-389-Obeticholic acid reduces matrix metalloproteinases activity via iNOS modulation in hepatic ischemia/reperfusion injury

Journal of Hepatology ◽

10.1016/s0618-8278(19)31608-1 ◽

2019 ◽

Vol 70 (1) ◽

pp. e805

Author(s):

Laura Giuseppina Di Pasqua ◽

Giuseppina Palladini ◽

Clarissa Berardo ◽

Veronica Siciliano ◽

Luciano Adorini ◽

...

Keyword(s):

Matrix Metalloproteinases ◽

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817

Surgery ◽

10.1016/j.surg.2005.10.002 ◽

2006 ◽

Vol 139 (5) ◽

pp. 653-664 ◽

Cited By ~ 15

Author(s):

Kengo Shirahane ◽

Koji Yamaguchi ◽

Kenichiro Koga ◽

Masato Watanabe ◽

Syoji Kuroki ◽

...

Keyword(s):

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Matrix Metalloproteinase Inhibitor ◽

Hepatic Ischemia ◽

Metalloproteinase Inhibitor ◽

Increase in transporter MATE-1 expression induced by obeticholic acid correlates with higher biliary excretion of asymmetric dimethylarginine during hepatic ischemia/reperfusion injury

10.1016/j.dld.2017.01.064 ◽

2017 ◽

Vol 49 (1) ◽

pp. e30

Author(s):

L.G. Di Pasqua ◽

C. Berardo ◽

V. Siciliano ◽

R. Viscusi ◽

V. Rizzo ◽

...

Keyword(s):

Reperfusion Injury ◽

Biliary Excretion ◽

Asymmetric Dimethylarginine ◽

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

OCA administration reduces lung matrix metalloproteinase activation following hepatic ischemia/reperfusion injury in rats

10.1016/j.dld.2020.12.099 ◽

2021 ◽

Vol 53 ◽

pp. S41

Author(s):

L.G. Di Pasqua ◽

C. Berardo ◽

G. Palladini ◽

M. Cagna ◽

L. Adorini ◽

...

Keyword(s):

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Hepatic Ischemia ◽

Lung Matrix ◽

Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury

PLoS ONE ◽

10.1371/journal.pone.0238543 ◽

2020 ◽

Vol 15 (9) ◽

pp. e0238543

Author(s):

Andrea Ferrigno ◽

Giuseppina Palladini ◽

Laura Giuseppina Di Pasqua ◽

Clarissa Berardo ◽

Plinio Richelmi ◽

...

Keyword(s):

Matrix Metalloproteinases ◽

Reperfusion Injury ◽

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

Further increase in biliary excretion of asymmetric dimethylarginine during hepatic ischemia/reperfusion injury by obeticholic acid, a farnesoid-X-receptor agonist

10.1016/j.dld.2015.12.128 ◽

2016 ◽

Vol 48 ◽

pp. e55

Author(s):

L.G. Di Pasqua ◽

C. Berardo ◽

V. Rizzo ◽

L. Adorini ◽

P. Richelmi ◽

...

Keyword(s):

Reperfusion Injury ◽

Biliary Excretion ◽

Receptor Agonist ◽

Asymmetric Dimethylarginine ◽

Ischemia Reperfusion ◽

Farnesoid X Receptor ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

INOS-mediated decrease of matrix metalloproteinase activity by obeticholic acid in hepatic ischemia/reperfusion

10.1016/j.dld.2018.11.121 ◽

2019 ◽

Vol 51 ◽

pp. e45

Author(s):

L.G. Di Pasqua ◽

G. Palladini ◽

C. Berardo ◽

V. Siciliano ◽

L. Adorini ◽

...

Keyword(s):

Ischemia Reperfusion ◽

Obeticholic Acid ◽

Hepatic Ischemia ◽

Metalloproteinase Activity