Aggravation of brain injury after transient focal ischemia in p53-deficient mice

2001 ◽  
Vol 88 (1-2) ◽  
pp. 54-61 ◽  
Author(s):  
Keiichiro Maeda ◽  
Ryuji Hata ◽  
Frank Gillardon ◽  
Konstantin-Alexander Hossmann
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Transient Focal Ischemia ◽  
Deficient Mice

PPBP [4-Phenyl-1-(4-phenylbutyl) Piperidine] Decreases Brain Injury After Transient Focal Ischemia in Rats

Stroke ◽  
1996 ◽  
Vol 27 (11) ◽  
pp. 2120-2123 ◽  
Author(s):  
Hiroshi Takahashi ◽  
Jeffrey R. Kirsch ◽  
Kenji Hashimoto ◽  
Edythe D. London ◽  
Raymond C. Koehler ◽  
...  
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Transient Focal Ischemia

Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia

2004 ◽  
Vol 363 (3) ◽  
pp. 218-223 ◽  
Author(s):  
Yumin Luo ◽  
Zhen Qin ◽  
Zhen Hong ◽  
Xinmin Zhang ◽  
Ding Ding ◽  
...  
Keyword(s):  
Brain Injury ◽  
Murine Model ◽  
Focal Ischemia ◽  
Ischemic Brain Injury ◽  
Astragaloside Iv ◽  
Ischemic Brain ◽  
Transient Focal Ischemia

scholarly journals Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats.

Stroke ◽  
1994 ◽  
Vol 25 (11) ◽  
pp. 2258-2264 ◽  
Author(s):  
T Nishikawa ◽  
J R Kirsch ◽  
R C Koehler ◽  
M Miyabe ◽  
R J Traystman
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Receptor Blockade ◽  
Aspartate Receptor ◽  
Transient Focal Ischemia

scholarly journals PPBP [4-Phenyl-1-(4-phenylbutyl) Piperidine], a Potent ς-Receptor Ligand, Decreases Brain Injury After Transient Focal Ischemia in Cats

Stroke ◽  
1995 ◽  
Vol 26 (9) ◽  
pp. 1676-1682 ◽  
Author(s):  
Hiroshi Takahashi ◽  
Jeffrey R. Kirsch ◽  
Kenji Hashimoto ◽  
Edythe D. London ◽  
Raymond C. Koehler ◽  
...  
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Receptor Ligand ◽  
Transient Focal Ischemia

scholarly journals Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

2011 ◽  
Vol 31 (7) ◽  
pp. 1578-1582 ◽  
Author(s):  
Ulrike Hoffmann ◽  
Jeong Hyun Lee ◽  
Tao Qin ◽  
Katharina Eikermann-Haerter ◽  
Cenk Ayata
Keyword(s):  
Blood Flow ◽  
Brain Injury ◽  
Spreading Depression ◽  
Infarct Volume ◽  
Ischemic Injury ◽  
Focal Ischemia ◽  
Stroke Outcome ◽  
Depolarization Wave ◽  
Transient Focal Ischemia

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.

??-Adrenoreceptor Antagonists Attenuate Brain Injury After Transient Focal Ischemia in Rats

2006 ◽  
Vol 103 (3) ◽  
pp. 658-663 ◽  
Author(s):  
Toru Goyagi ◽  
Tetsu Kimura ◽  
Toshiaki Nishikawa ◽  
Yoshitsugu Tobe ◽  
Yoko Masaki
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Transient Focal Ischemia
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