P-752 Biomarkers for small cell lung cancer (SCLC): DNA methylationand GD2 synthase transcript levels

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S316-S317 ◽  
Author(s):  
L. Chen ◽  
L. Krug ◽  
C. Azzoli ◽  
I. Cheung ◽  
S. Park ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Transcript Levels ◽  
P 752

scholarly journals MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung Cancer

2015 ◽  
Vol 37 (1) ◽  
pp. 342-352 ◽  
Author(s):  
Chongbiao Huang ◽  
Ruijue Ma ◽  
Jie Yue ◽  
Na Li ◽  
Zengxun Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Mrna Level ◽  
Small Cell ◽  
Brdu Incorporation ◽  
Small Cell Lung ◽  
Nsclc Tissue ◽  
Transcript Levels ◽  
Cellular Effects

Background/Aims: To investigate the expression, clinical significance and the cellular effects of miR-497 in non-small cell lung cancer (NSCLC). Methods: NSCLC cells were transiently transfected with miR-497 mimics or siRNA to up-regulate or down-regulate expression. Quantitative real-time PCR (qRT-PCR) was used to detect the mRNA level of miR-497. Luciferase assays, colony formation assays and BrdU incorporation assays were performed to identify the targets and role of miR-497 in NSCLC cells. Finally, the abundance of miR-497 was analyzed in a total of 51 NSCLC specimens. Results: The transcript levels of miR-497 were significantly decreased in NSCLC tissue (25/30; 83.3%). Low miR-497 levels in tumor tissue correlated with advanced pT stage. Additionally, miR-497 transcript levels correlated with overall survival of NSCLC patients (n = 51, p = 0.022). Overexpression of miR-497 inhibited the proliferation of NSCLC cell and down-regulation of miR-497 resulted in elevated NSCLC growth. Exogenous over-expression of YAP1 partially eliminated miR-497-induced cell growth. Conclusion: miR-497 plays an important role in inhibiting the proliferation of NSCLC by targeting YAP1. Our results suggest that miR-497 is a potential therapeutic target in treating patients with NSCLC.

Abstract #829: Effect of Body Mass Index (BMI) and Lipids on Non-Small Cell Lung Cancer (NSCLC) Survival

2016 ◽  
Vol 22 ◽  
pp. 176
Author(s):  
Genevieve Streb ◽  
Narjust Duma ◽  
Natasha Piracha ◽  
Sejal Kothadia ◽  
Komal Patel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Body Mass Index ◽  
Small Cell Lung Cancer ◽  
Body Mass ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
Sign in / Sign up

Export Citation Format

Share Document