Androgen Receptor and Calcitonin Gene-Related Peptide in Neurons of the Genitofemoral Nerve During Testicular Descent Induced with Human Chorionic Gonadotropin

2003 ◽  
Vol 34 (3) ◽  
pp. 166-170 ◽  
Author(s):  
Rosa Marı́a Vigueras ◽  
Norma Moreno-Mendoza ◽  
Gabriela Reyes ◽  
Horacio Merchant-Larios
Keyword(s):  
Androgen Receptor ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Calcitonin Gene Related Peptide ◽  
Testicular Descent ◽  
Genitofemoral Nerve ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Effect of an anti-androgen on testicular descent and inguinal closure in a marsupial, the tammar wallaby (Macropus eugenii)

Reproduction ◽  
2002 ◽  
pp. 865-874 ◽  
Author(s):  
D Coveney ◽  
G Shaw ◽  
JM Hutson ◽  
MB Renfree
Keyword(s):  
Dorsal Root ◽  
Inguinal Canal ◽  
Prostate Gland ◽  
Tammar Wallaby ◽  
Calcitonin Gene Related Peptide ◽  
Hormonal Control ◽  
Testicular Descent ◽  
Genitofemoral Nerve ◽  
Related Peptide ◽  
Calcitonin Gene

Androgens are essential for testicular descent in eutherian mammals, but little is known about its hormonal control in marsupials. This study reports the effects of daily treatment with the anti-androgen flutamide (10 mg kg(-1)) from day 9 to day 75 after birth on the descent of the testis and inguinal closure in tammar wallabies. By day 75 after birth, the testes of control males had descended and the prostate gland was well developed. The testes of all flutamide-treated males had passed through the inguinal canal and were situated in the base of the scrotum. Three of the nine flutamide-treated males had unilateral inguinal hernias. The size of the inguinal canal, regardless of whether a hernia was present, was significantly wider than that of control males. Development of the prostate gland was significantly inhibited. By day 75 after birth, the phallus was significantly longer in control males than in females, whereas the phallus of flutamide-treated males was similar to that of control females. In flutamide-treated males, the lumbar 1 dorsal root ganglia was feminized and significantly fewer cell bodies expressed calcitonin gene- related peptide. As the anti-androgen treatment resulted in a reduction in the number of calcitonin gene-related peptide-positive cell bodies in the dorsal root ganglion supplying the genitofemoral nerve, the process of inguinal closure in tammar wallabies may be mediated by calcitonin gene-related peptide via the genitofemoral nerve, as indicated in humans. Flutamide treatment inhibited development of the prostate gland and phallus, which are both androgen-dependent structures, but it did not affect the normal descent of the testis, indicating that testicular descent can proceed when the action of androgens is blocked.

Localization of calcitonin gene-related peptide within the genitofemoral nerve in immature rats

1999 ◽  
Vol 34 (6) ◽  
pp. 986-991 ◽  
Author(s):  
Bernadette Schwindt ◽  
Pamela J Farmer ◽  
Lisa M Watts ◽  
Zoltan Hrabovszky ◽  
John M Hutson
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Genitofemoral Nerve ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Immature Rats

A new role for androgen in testicular descent: permitting gubernacular cell proliferation in response to the neuropeptide, calcitonin gene–related peptide

2006 ◽  
Vol 41 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Natalie S. Shenker ◽  
Jenny Huynh ◽  
Pamela J. Farmer ◽  
John M. Hutson
Keyword(s):  
Cell Proliferation ◽  
Calcitonin Gene Related Peptide ◽  
Testicular Descent ◽  
Related Peptide ◽  
Calcitonin Gene

The Role of the Genitofemoral Nerve and Calcitonin Gene-Related Peptide in Congenitally Cryptorchid Mutant TS Rats

1995 ◽  
pp. 734-737 ◽  
Author(s):  
Masaru Terada ◽  
John M. Hutson ◽  
Pamela J. Farmer ◽  
Day Way Goh
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Genitofemoral Nerve ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene–related peptide stimulates mitosis in the tip of the rat gubernaculum in vitro and provides the chemotactic signals to control gubernacular migration during testicular descent

2008 ◽  
Vol 43 (8) ◽  
pp. 1533-1539 ◽  
Author(s):  
Eric X.Z. Yong ◽  
Jenny Huynh ◽  
Pamela Farmer ◽  
Sim Y. Ong ◽  
Magdy Sourial ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Testicular Descent ◽  
Related Peptide ◽  
Calcitonin Gene
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