926 Importance of plaque composition on the immune-inflammatory response related to coronary stent implantation in stable angina patients

AbstractCoronary angioplasty is known to mediate an inflammatory response. Recently, we have characterized the transient systemic inflammatory response after coronary stent implantation in patients with unstable angina by measuring different soluble protein markers. In the present study we have characterized the expression of various cellular activation markers in neutrophils, monocytes and lymphocytes from the same group of patients. Peripheral blood samples were taken before and 24 h, 48 h and 7 days after successful coronary stenting in 58 patients. Cell surface markers (CD11b/CD18 and CD38) were analyzed by flow cytometry to determine the activation of neutrophils, monocytes and T lymphocytes. We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days. However, T lymphocytes were not found to be activated. These results suggest that coronary stent implantation induces a different pattern inducing soluble and cellular inflammation markers, and therefore, they should be taken into account in patients undergoing stent implantation to study clinical correlations.

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Inflammatory Response to Coronary Stent Implantation in Patients with Unstable Angina

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2002.132 ◽

2002 ◽

Vol 40 (8) ◽

Cited By ~ 12

Author(s):

Víctor Sánchez-Margalet ◽

José M. Cubero ◽

Consuelo Martín-Romero ◽

José Cubero ◽

José M. Cruz-Fernández ◽

...

Keyword(s):

Inflammatory Response ◽

Unstable Angina ◽

Stent Implantation ◽

Coronary Stent ◽

Coronary Stent Implantation

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Is In-Stent Restenosis After a Successful Coronary Stent Implantation Due to Stable Angina Associated With TG/HDL-C Ratio?

Angiology ◽

10.1177/0003319716689366 ◽

2017 ◽

Vol 68 (9) ◽

pp. 816-822 ◽

Cited By ~ 3

Author(s):

Harun Kundi ◽

Ahmet Korkmaz ◽

Ahmet Balun ◽

Hulya Cicekcioglu ◽

Emrullah Kiziltunc ◽

...

Keyword(s):

Stent Implantation ◽

Stable Angina ◽

Large Scale ◽

Cox Regression ◽

Coronary Stent ◽

Cox Regression Analysis ◽

Stent Restenosis ◽

Coronary Stent Implantation ◽

The Impact ◽

In Stent Restenosis

We examined the impact of the preprocedural triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio on risk of in-stent restenosis (ISR). Patients with typical anginal symptoms and/or positive treadmill or myocardial perfusion scintigraphy test results who underwent successful coronary stent implantation due to stable angina were examined; 1341 patients were enrolled. The hospital files of the patients were used to gather data. Cox regression analysis showed that the TG/HDL-C ratio was independently associated with the presence of ISR ( P < .001). Moreover, diabetes mellitus ( P = .007), smaller stent diameter ( P = .046), and smoking status ( P = .001) were also independently associated with the presence of ISR. Using a cutoff of 3.8, the TG/HDL-C ratio predicted the presence of ISR with a sensitivity of 71% and a specificity of 68%. Also, the highest quartile of TG/HDL-C ratio had the highest rate of ISR ( P < .001). Measuring preprocedural TG/HDL-C ratio, in fasting or nonfasting samples, could be beneficial for the risk assessment of ISR. However, further large-scale prospective studies are required to establish the exact role of this simple, easily calculated, and reproducible parameter in the pathogenesis of ISR.

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