P2914 The L-type calcium channel inhibitor diltiazem prevents diastolic dysfunction and stress-induced cardiac decompensation in a mouse model of familial hypertrophic cardiomyopathy

2003 ◽  
Vol 24 (5) ◽  
pp. 561
Author(s):  
C TSCHOEPE
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Calcium Channel ◽  
Diastolic Dysfunction ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Cardiac Decompensation

scholarly journals Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

1998 ◽  
Vol 101 (8) ◽  
pp. 1775-1783 ◽  
Author(s):  
M Spindler ◽  
K W Saupe ◽  
M E Christe ◽  
H L Sweeney ◽  
C E Seidman ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Diastolic Dysfunction ◽  
Familial Hypertrophic Cardiomyopathy

scholarly journals Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

2009 ◽  
Vol 82 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Theodore P. Abraham ◽  
Michelle Jones ◽  
Katarzyna Kazmierczak ◽  
Hsin-Yueh Liang ◽  
Aurelio C. Pinheiro ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Transgenic Model

scholarly journals Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N

2011 ◽  
Vol 301 (4) ◽  
pp. H1646-H1655 ◽  
Author(s):  
Robert D. Gaffin ◽  
Shamim A. K. Chowdhury ◽  
Marco S. L. Alves ◽  
Fernando A. L. Dias ◽  
Cibele T. D. Ribeiro ◽  
...  
Keyword(s):  
Heart Rate ◽  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Troponin I ◽  
Left Ventricular ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Maximal Rate ◽  
Western Blots ◽  
Nicotine Administration ◽  
Acute And Chronic Effects

The effects of nicotine (NIC) on normal hearts are fairly well established, yet its effects on hearts displaying familial hypertrophic cardiomyopathy have not been tested. We studied both the acute and chronic effects of NIC on a transgenic (TG) mouse model of FHC caused by a mutation in α-tropomyosin (Tm; i.e., α-Tm D175N TG, or Tm175). For acute effects, intravenously injected NIC increased heart rate, left ventricular (LV) pressure, and the maximal rate of LV pressure increase (+dP/d t) in non-TG (NTG) and Tm175 mice; however, Tm175 showed a significantly smaller increase in the maximal rate of LV pressure decrease (−dP/ dt) compared with NTGs. Western blots revealed phosphorylation of phospholamban Ser16 and Thr17 residue increased in NTG mice following NIC injection but not in Tm175 mice. In contrast, phosphorylation of troponin I at serine residues 23 and 24 increased equally in both NTG and Tm175. Thus the attenuated increase in relaxation in Tm175 mice following acute NIC appears to result primarily from attenuated phospholamban phosphorylation. Chronic NIC administration (equivalent to smoking 2 packs of cigarettes/day for 4 mo) also increased +dP/dt in NTG and Tm175 mice compared with chronic saline. However, chronic NIC had little effect on heart rate, LV pressure, −dP/d t, LV wall and chamber dimensions, or collagen content for either group of mice.

scholarly journals Severe Heart Failure and Early Mortality in a Double-Mutation Mouse Model of Familial Hypertrophic Cardiomyopathy

Circulation ◽  
2008 ◽  
Vol 117 (14) ◽  
pp. 1820-1831 ◽  
Author(s):  
Tatiana Tsoutsman ◽  
Matthew Kelly ◽  
Dominic C.H. Ng ◽  
Ju-En Tan ◽  
Emily Tu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Severe Heart Failure ◽  
Early Mortality ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Double Mutation

Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy

2006 ◽  
Vol 41 (4) ◽  
pp. 623-632 ◽  
Author(s):  
Tatiana Tsoutsman ◽  
Jessica Chung ◽  
Alessandra Doolan ◽  
Lan Nguyen ◽  
Iwan A. Williams ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Familial Hypertrophic Cardiomyopathy

A mouse model of familial hypertrophic cardiomyopathy caused by a α-tropomyosin mutation

2003 ◽  
pp. 33-42
Author(s):  
Rethinasamy Prabhakar ◽  
Natalia Petrashevskaya ◽  
Arnold Schwartz ◽  
Bruce Aronow ◽  
Greg P. Boivin ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Familial Hypertrophic Cardiomyopathy

scholarly journals Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging

2003 ◽  
Vol 50 (3) ◽  
pp. 638-642 ◽  
Author(s):  
Daniel B. Ennis ◽  
Frederick H. Epstein ◽  
Peter Kellman ◽  
Lameh Fananapazir ◽  
Elliot R. McVeigh ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Familial Hypertrophic Cardiomyopathy
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