Background:
The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and
dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches
described different transduction mechanisms in the progression of cancer and diabetes.
Methodology:
We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation
and determined the crosstalk and common pathway in diabetes and cancer.
Results:
We showed that according to numerous past studies, the proteins participate in the signaling networks for both
diseases.
Conclusion:
There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates
and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological
studies.
P1 and P2 purinoceptors involve distinct intracellular signal transduction mechanisms in vertebrate nerve cells
