Long-lasting protective immunity against rodent malaria parasite infection at the blood stage by recombinant BCG secreting merozoite surface protein-1

Vaccine ◽  
1999 ◽  
Vol 18 (9-10) ◽  
pp. 832-834 ◽  
Author(s):  
Sohkichi Matsumoto ◽  
Hideharu Yukitake ◽  
Hiroji Kanbara ◽  
Takeshi Yamada
Keyword(s):  
Protective Immunity ◽  
Malaria Parasite ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Parasite Infection ◽  
Rodent Malaria Parasite ◽  
Rodent Malaria ◽  
Merozoite Surface Protein 1 ◽  
Malaria Parasite Infection ◽  
Recombinant Bcg

scholarly journals Association between Protection against Clinical Malaria and Antibodies to Merozoite Surface Antigens in an Area of Hyperendemicity in Myanmar: Complementarity between Responses to Merozoite Surface Protein 3 and the 220-Kilodalton Glutamate-Rich Protein

2004 ◽  
Vol 72 (1) ◽  
pp. 247-252 ◽  
Author(s):  
Soe Soe ◽  
Michael Theisen ◽  
Christian Roussilhon ◽  
Khin-Saw- Aye ◽  
Pierre Druilhe
Keyword(s):  
Protective Immunity ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Clinical Malaria ◽  
Strong Response ◽  
Vaccine Candidates ◽  
Follow Up Study ◽  
Merozoite Surface Protein 1 ◽  
Complementary Effect

ABSTRACT We performed a longitudinal clinical and parasitological follow-up study in OoDo, a village in southeast Asia in which malaria is hyperendemic, in order to assess the association between protection against malaria attacks and antibodies to three currently evaluated vaccine candidates, merozoite surface protein 1 (MSP1), MSP3, and the 220-kDa glutamate-rich protein (GLURP) from Plasmodium falciparum. Our results showed that the levels of cytophilic immunoglobulin G3 (IgG3) antibodies against conserved regions of MSP3 and GLURP were significantly correlated with protection against clinical P. falciparum malaria. In contrast, the levels of noncytophilic IgG4 antibodies against GLURP increased with the number of malaria attacks. Furthermore, we observed a complementary effect of the MSP3- and GLURP-specific IgG3 antibodies in relation to malaria protection. In the individuals that did not respond to one of the antigens, a strong response to the other antigen was consistently detected and was associated with protection, suggesting that induction of antibodies against both MSP3 and GLURP could be important for the development of protective immunity. The complementarity of the responses to the two main targets of antibody-dependent cellular inhibition identified to date provides the first rational basis for combining these two antigens in a hybrid vaccine formulation.

The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria

Parasitology ◽  
2009 ◽  
Vol 136 (12) ◽  
pp. 1445-1456 ◽  
Author(s):  
A. A. HOLDER
Keyword(s):  
Protective Immunity ◽  
First Generation ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Carboxy Terminus ◽  
Vaccine Candidates ◽  
Merozoite Surface Protein 1 ◽  
Early Results ◽  
Experimental Approaches

SUMMARYOver the last 30 years, evidence has been gathered suggesting that merozoite surface protein 1 (MSP1) is a target of protective immunity against malaria. In a variety of experimental approaches usingin vitromethodology, animal models and sero-epidemiological techniques, the importance of antibody against MSP1 has been established but we are still finding out what are the mechanisms involved. Now that clinical trials of MSP1 vaccines are underway and the early results have been disappointing, it is increasingly clear that we need to know more about the mechanisms of immunity, because a better understanding will highlight the limitations of our current assays and identify the improvements required. Understanding the structure of MSP1 will help us design and engineer better antigens that are more effective than the first generation of vaccine candidates. This review is focused on the carboxy-terminus of MSP1.

scholarly journals Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells

Blood ◽  
2015 ◽  
Vol 125 (17) ◽  
pp. 2704-2711 ◽  
Author(s):  
Michael R. Baldwin ◽  
Xuerong Li ◽  
Toshihiko Hanada ◽  
Shih-Chun Liu ◽  
Athar H. Chishti
Keyword(s):  
Blood Cells ◽  
Malaria Parasite ◽  
Essential Role ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Glycophorin A ◽  
Parasite Invasion ◽  
Merozoite Surface Protein 1 ◽  
Key Points ◽  
Human Rbcs

Key PointsThe N-terminal subunit of MSP1 binds to a specific polypeptide region of GPA during merozoite invasion of human RBCs. The GPA–band 3 complex plays an essential role during malaria parasite invasion.

scholarly journals Interleukin-27-Producing CD4 + T Cells Regulate Protective Immunity during Malaria Parasite Infection

Immunity ◽  
2016 ◽  
Vol 44 (3) ◽  
pp. 672-682 ◽  
Author(s):  
Daisuke Kimura ◽  
Mana Miyakoda ◽  
Kazumi Kimura ◽  
Kiri Honma ◽  
Hiromitsu Hara ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Protective Immunity ◽  
Malaria Parasite ◽  
Parasite Infection ◽  
Malaria Parasite Infection ◽  
Interleukin 27
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