133 Development of small interfering RNA (SIRNAS) against full-length hepatitis C virus 1A strain

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 220-220 ◽  
Author(s):  
R PRABHU ◽  
P VITAL ◽  
F ERIK ◽  
R GARRY ◽  
F BASTIAN ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Small Interfering Rna ◽  
Full Length ◽  
Interfering Rna

Small interfering RNA effectively inhibits protein expression and negative strand RNA synthesis from a full-length hepatitis C virus clone

2005 ◽  
Vol 76 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Ramesh Prabhu ◽  
Padmaja Vittal ◽  
Qinyan Yin ◽  
Erik Flemington ◽  
Robert Garry ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Expression ◽  
Small Interfering Rna ◽  
Rna Synthesis ◽  
Full Length ◽  
Negative Strand ◽  
Interfering Rna ◽  
Virus Clone

scholarly journals Requirement for Chloride Channel Function during the Hepatitis C Virus Life Cycle

2015 ◽  
Vol 89 (7) ◽  
pp. 4023-4029 ◽  
Author(s):  
Zsofia Igloi ◽  
Bjorn-Patrick Mohl ◽  
Jonathan D. Lippiat ◽  
Mark Harris ◽  
Jamel Mankouri
Keyword(s):  
Plasma Membrane ◽  
Life Cycle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chloride Channel ◽  
Small Interfering Rna ◽  
Channel Blockers ◽  
Virus Life Cycle ◽  
Channel Inhibition ◽  
Interfering Rna

Hepatocytes express an array of plasma membrane and intracellular ion channels, yet their role during the hepatitis C virus (HCV) life cycle remains largely undefined. Here, we show that HCV increases intracellular hepatic chloride (Cl−) influx that can be inhibited by selective Cl−channel blockers. Through pharmacological and small interfering RNA (siRNA)-mediated silencing, we demonstrate that Cl−channel inhibition is detrimental to HCV replication. This represents the first observation of the involvement of Cl−channels during the HCV life cycle.

Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology

Hepatology ◽  
2007 ◽  
Vol 45 (6) ◽  
pp. 1413-1421 ◽  
Author(s):  
Teresa I. Ng ◽  
Hongmei Mo ◽  
Tami Pilot-Matias ◽  
Yupeng He ◽  
Gennadiy Koev ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Small Interfering Rna ◽  
Interfering Rna ◽  
Host Genes

138 Inhibition of intracellular hepatitis C virus replication by adenovirus delivery of vector-derived small interfering RNA

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 222-222
Author(s):  
N SAKAMOTO ◽  
Y TANABE ◽  
N ENOMOTO ◽  
S MAEKAWA ◽  
M KUROSAKI ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Small Interfering Rna ◽  
Interfering Rna
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