Successful treatment of acute inferior vena cava and unilateral renal vein thrombosis by local infusion of recombinant tissue plasminogen activator

SummaryThe bioavailability of human recombinant tissue plasminogen activator (rt-PA) in rats was measured after subcutaneous (s.c.) and intramuscular (i.m.) injection. Rt-PA was absorbed after both i.m. and s.c. injection, giving peak plasma concentrations within 30 min and 1 h, respectively, with detectable concentrations up to 6 h. These peak values of bioavailable t-PA were obtained in a functional fibrin plate assay of euglobulin precipitates and expressed as +88% and +243% (for s.c. and i.m. routes respectively) above basal rat fibrinolytic activity. Prior injection of rt-PA, s.c. or i.m., significantly reduced the weights of thrombi induced in the inferior vena cava after injection.

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Endovascular Treatment of an Extensive Iliocaval and Renal Vein Thrombosis Secondary to Inferior Vena Cava Stenosis and May-Thurner Type Iliac Vein Compression: A Case Report

Vascular and Endovascular Surgery ◽

10.1177/1538574419900613 ◽

2020 ◽

Vol 54 (3) ◽

pp. 297-300 ◽

Cited By ~ 1

Author(s):

Thomas Frederick Barge ◽

Emma Wilton ◽

Andrew Wigham

Keyword(s):

Inferior Vena Cava ◽

Renal Vein ◽

Inferior Vena ◽

Left Renal Vein ◽

Vena Cava ◽

Iliac Vein ◽

Renal Vein Thrombosis ◽

Endovascular Techniques ◽

Vein Thrombosis ◽

Iliac Vein Compression

A 23-year-old presenting with an acute history of back pain, leg swelling, and claudication was diagnosed with an extensive iliocaval thrombosis, extending from the popliteal veins into the inferior vena cava (IVC) and left renal vein. He was treated with a combination of endovascular techniques, including EKOS and AngioJet. An underlying congenital IVC stenosis and May-Thurner type iliac vein compression were subsequently treated with venoplasty and stenting. To our knowledge, this is the first report of the use of EKOS for renal vein thrombosis and we highlight the complementary nature of different endovascular techniques for managing complex venous thrombotic disease.

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Acute Bilateral Renal Vein Thrombosis Superimposed on Calcified Thrombus of the Inferior Vena Cava in a Patient with Membranous Lupus Nephritis

Nephrology Dialysis Transplantation ◽

10.1093/ndt/5.suppl_1.71 ◽

1990 ◽

Vol 5 (suppl 1) ◽

pp. 71-74 ◽

Cited By ~ 7

Author(s):

L. Cagnoli ◽

G. Viglietta ◽

G. Madia ◽

A. Gattiani ◽

C. Orsi ◽

...

Keyword(s):

Lupus Nephritis ◽

Inferior Vena Cava ◽

Renal Vein ◽

Inferior Vena ◽

Vena Cava ◽

Renal Vein Thrombosis ◽

Vein Thrombosis ◽

Calcified Thrombus ◽

Membranous Lupus Nephritis

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Non Catether Induced Renal and Inferior Vena Cava Trombosis in a Neonate: A Case Report

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.306 ◽

2018 ◽

Vol 6 (9) ◽

pp. 1678-1681 ◽

Cited By ~ 1

Author(s):

Natasha Aluloska ◽

Snezana Janchevska ◽

Velibor Tasic

Keyword(s):

Inferior Vena Cava ◽

Renal Vein ◽

Inferior Vena ◽

Abdominal Mass ◽

Vena Cava ◽

Renal Vein Thrombosis ◽

Renal Ultrasound ◽

Gross Hematuria ◽

Vein Thrombosis ◽

Vena Cava Thrombosis

BACKGROUND: Neonatal renal vein thrombosis is the most common vascular condition in the newborn kidney, which could lead to serious complication in infants.CASE REPORT: We report a case of the unilateral renal vein and inferior vena cava thrombosis, presented with gross hematuria and thrombocytopenia in a neonate. The neonate was a macrosomic male born to a mother with hyperglycemia in pregnancy. The baby was born with perinatal asphyxia and early neonatal infection and massive hematuria. Clinical and laboratory examination showed enlarged kidney having corticomedullary differentiation diminished and azotemia. Diagnosis of renal vein thrombosis was suspected by renal ultrasound and confirmed by magnetic urography. Prothrombotic risk factors were evaluated. The child is being managed conservatively. Measures aimed at the prevention of end-stage renal disease because of its poor outcome were highlighted. Despite anticoagulant therapy, the right kidney developed areas of scarring and then atrophy. CONCLUSION: In this work, we present a patient with multiple entities in the aetiology of non-catheter induced renal and vena cava thrombosis in a neonate. Clinicians should suspect renal vein thrombosis in neonates when presented with early postnatal gross hematuria, palpable abdominal mass and thrombopenia.

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