Bioavailability in Rats of Human Recombinant Tissue Plasminogen Activator After Subcutaneous and Intramuscular Injection
1986 ◽
Vol 56
(03)
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pp. 299-301
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Keyword(s):
SummaryThe bioavailability of human recombinant tissue plasminogen activator (rt-PA) in rats was measured after subcutaneous (s.c.) and intramuscular (i.m.) injection. Rt-PA was absorbed after both i.m. and s.c. injection, giving peak plasma concentrations within 30 min and 1 h, respectively, with detectable concentrations up to 6 h. These peak values of bioavailable t-PA were obtained in a functional fibrin plate assay of euglobulin precipitates and expressed as +88% and +243% (for s.c. and i.m. routes respectively) above basal rat fibrinolytic activity. Prior injection of rt-PA, s.c. or i.m., significantly reduced the weights of thrombi induced in the inferior vena cava after injection.
2006 ◽
Vol 17
(3)
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pp. 209-212
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1998 ◽
Vol 32
(6)
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pp. 1075-1079
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2002 ◽
Vol 38
(5)
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pp. 431-435
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2005 ◽
Vol 27
(12)
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pp. 692-695
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1999 ◽
Vol 21
(4)
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pp. 319
1991 ◽
Vol 66
(03)
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pp. 292-294
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1988 ◽
Vol 60
(01)
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pp. 107-112
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1989 ◽
Vol 61
(01)
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pp. 131-136
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1971 ◽
Vol 25
(03)
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pp. 469-480
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