scholarly journals Estimation and model selection based inference in single and multiple threshold models

2002 ◽  
Vol 110 (2) ◽  
pp. 319-352 ◽  
Author(s):  
Jesús Gonzalo ◽  
Jean-Yves Pitarakis
Keyword(s):  
Model Selection ◽  
Threshold Models ◽  
Multiple Threshold

Genetic Models of Affective Disorder: Application to Twin Data

1980 ◽  
Vol 29 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Miron Baron
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Monozygotic Twins ◽  
Threshold Models ◽  
Twin Data ◽  
Bipolar Illness ◽  
Major Locus ◽  
Unipolar Disorder ◽  
Locus Model ◽  
Multiple Threshold

Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.

The Genetics of Hypodontia

1974 ◽  
Vol 53 (4) ◽  
pp. 781-785 ◽  
Author(s):  
Brian K. Suarez ◽  
M. Anne Spence
Keyword(s):  
Major Gene ◽  
Large Body ◽  
Family Data ◽  
Threshold Models ◽  
Gene Model ◽  
Polygenic Model ◽  
Multiple Threshold ◽  
Better Than

A large body of family data was analyzed to explain the genetics of hypodontia. Two multiple threshold models that were developed for quasicontinuous traits were used. The data fit the polygenic model much better than they fit the single major gene model.

scholarly journals Model Selection in Threshold Models

2001 ◽  
Vol 22 (6) ◽  
pp. 733-754 ◽  
Author(s):  
George Kapetanios
Keyword(s):  
Model Selection ◽  
Threshold Models

Multiple threshold models for the affective disorders: The Yale-NIMH collaborative family study

1985 ◽  
Vol 19 (4) ◽  
pp. 533-546 ◽  
Author(s):  
R.Arlen Price ◽  
Kenneth K. Kidd ◽  
David L. Pauls ◽  
Elliot S. Gershon ◽  
Brigitte A. Prusoff ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Family Study ◽  
Threshold Models ◽  
Multiple Threshold
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