affective disorder
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Author(s):  
Nele Goldbach ◽  
Andreas Reif ◽  
Hanna Preuss ◽  
Mira Erhart ◽  
Kirsten Zabel ◽  
...  

2021 ◽  
pp. 175407392110578
Author(s):  
Güler Cansu Ağören

Phenomenologists define social impairments as key aspects of depression and argue that depression is irreducible to the individual. In this article I aim to further elaborate this non-reductionist notion of depression by claiming that depression not only corresponds to an impaired experience of social relations, but also arises from a socially impaired world. To pursue this goal, I will challenge the understanding of depression as an affective disorder blocking the affective communication between individual and environment. I will redefine feelings of depression as situated affections, and hence suggest that (1) they are products of the individual's situatedness in a depressogenic environment and (2) they function in initiating an active withdrawal from such environment.


2021 ◽  
Author(s):  
Birgit Ludwig ◽  
Laura Carlberg ◽  
Klemens Kienesberger ◽  
Patrick Swoboda ◽  
Marleen Swoboda ◽  
...  

Abstract Background: Oxytocin (OXT) is a neuropeptide and hormone involved in emotional functioning and also seems to play a role in moderating the stress response. Both preclinical and clinical studies point to an increased methylation status of the Oxytocin receptor (OXTR) promoter region with concomitant deficits in social, cognitive and emotional functioning. We hypothesize that methylation levels (%) of the oxytocin receptor promoter region correlate with the severity of depression symptoms within this present sample of affective disorder patients. Methodology: Eight hundred forty six Caucasian affective disorder patients were recruited at the Department of Psychiatry and Psychotherapy of the Medical University Vienna, the Karl Landsteiner University for Health and Science and Zentrum für seelische Gesundheit, BBRZ-Med Leopoldau. The assessment included an assemblage of psychiatric interviews (e.g. SCAN, HAMD, CTQ) and concomitantly DNA samples of peripheral blood cells were collected for Multiplexed and Sensitive DNA Methylation Testing. Results: Our data suggests a positive but not significant association between OXTR promoter Exons 1-3 methylation levels and severity of depression symptoms in affective disorder patients. Conclusions: Our findings contribute to elucidate the role of OXTR in affective disorders, but further longitudinal studies in particular are necessary to broaden the current state of knowledge.


2021 ◽  
Vol 34 (6) ◽  
pp. e100663
Author(s):  
Surbhi Batra ◽  
Sumit Kumar ◽  
Lokesh Singh Shekhawat

Neurocysticercosis is the most common neuro-parasitosis caused by the larval stage of Taenia solium. The most common manifestations include seizures and hydrocephalus. Psychiatric abnormalities are relatively rare but depressive symptoms are frequent in patients with neurocysticercosis. However, mania as a presentation is relatively rare. Pregnancy and the postpartum period are relatively vulnerable times and they can lead to reactivation of existing neurocysterci lesions. We are discussing the case of a 23-year-old female patient with neurocysticercosis leading to the reactivation of lesions in the peripartum and postpartum period leading to bipolar affective disorder. Improvement in the patient was seen with a combination of antipsychotics, antihelmintics, antiepileptics and steroids, along with improved radiological signs of neurocysterci lesions. Although neurocysticercosis is a common illness, its prevalence presenting as a manic episode is merely 2.6% and, hence, missed easily. Therefore, it is important to rule out organic aetiology in patients even with a classic presentation of bipolar affective disorder and those having any other neurological symptoms and signs.


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