Multiple threshold models for the affective disorders: The Yale-NIMH collaborative family study

1985 ◽  
Vol 19 (4) ◽  
pp. 533-546 ◽  
Author(s):  
R.Arlen Price ◽  
Kenneth K. Kidd ◽  
David L. Pauls ◽  
Elliot S. Gershon ◽  
Brigitte A. Prusoff ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Family Study ◽  
Threshold Models ◽  
Multiple Threshold

Genetic Models of Affective Disorder: Application to Twin Data

1980 ◽  
Vol 29 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Miron Baron
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Monozygotic Twins ◽  
Threshold Models ◽  
Twin Data ◽  
Bipolar Illness ◽  
Major Locus ◽  
Unipolar Disorder ◽  
Locus Model ◽  
Multiple Threshold

Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.

The relationship between obsessive–compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study

2001 ◽  
Vol 31 (3) ◽  
pp. 481-487 ◽  
Author(s):  
G. NESTADT ◽  
J. SAMUELS ◽  
M. A. RIDDLE ◽  
K.-Y. LIANG ◽  
O. J. BIENVENU ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Affective Disorders ◽  
Substance Dependence ◽  
Separation Anxiety ◽  
Family Study ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Relationship

Objective. This study investigates the relationship of specific anxiety and affective disorders to obsessive–compulsive disorder (OCD) in a blind, controlled family study.Method. Eighty case and 73 control probands, as well as 343 case and 300 control first-degree relatives of these probands, participated in the study. Subjects were examined by psychologists or psychiatrists using the Schedule for Affective Disorder and Schizophrenia-Lifetime Anxiety version (SADS-LA). Two experienced psychiatrists independently reviewed all clinical materials, and final diagnoses were made according to DSM-IV criteria, by consensus procedure.Results. Except for bipolar disorder, all anxiety and affective disorders investigated were more frequent in case than control probands. Substance dependence disorders were not more frequent. Generalized anxiety disorder (GAD), panic disorder, agoraphobia, separation anxiety disorder (SAD) and recurrent major depression were more common in case than control relatives. These disorders occurred more frequently if the relative was diagnosed with OCD. Only GAD and agoraphobia were more frequent in case relatives independent of OCD.Conclusion. GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome.

A Family Study of Bipolar II Disorder

1984 ◽  
Vol 145 (1) ◽  
pp. 49-54 ◽  
Author(s):  
W. Coryell ◽  
J. Endicott ◽  
T. Reich ◽  
N. Andreasen ◽  
M. Keller
Keyword(s):  
Major Depression ◽  
Diagnostic Criteria ◽  
Small Proportion ◽  
Affective Disorders ◽  
Family Study ◽  
Collaborative Study ◽  
Bipolar Ii Disorder ◽  
Bipolar Illness ◽  
Bipolar Ii ◽  
The Family

SummaryProfessional raters who were blind to proband diagnosis used the schedule for affective disorders and schizophrenia (SADS-L) and the Research Diagnostic Criteria (RDC) to evaluate 1, 210 first-degree relatives of 327 probands with primary major depression, participating in the family sub-study of the NIMH Collaborative Study of the Affective Disorders – Clinical Branch. Bipolar II probands were significantly more likely to have bipolar II relatives than were non-bipolar or bipolar I probands. Bipolar II probands were slightly more likely than non-bipolar probands and slightly less likely than bipolar I probands to have relatives with bipolar I illness. Similar patterns have emerged in two other recently reported family studies of bipolar II illness. Taken together, these data suggest heterogeneity among patients with bipolar II depression. Some appear to be genotypes for bipolar I illness, while a small proportion may be genotypes for non-bipolar illness. A third group, of undetermined size, may breed true.

Transmission of affective disorders: An application of segregation analysis to blind family study data

1985 ◽  
Vol 19 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Ming T. Tsuang ◽  
Kathleen D. Bucher ◽  
Jerome A. Fleming ◽  
Stephen V. Faraone
Keyword(s):  
Affective Disorders ◽  
Segregation Analysis ◽  
Family Study ◽  
Study Data

Description of the National Institute of Mental Health family study of affective disorders

1989 ◽  
Vol 6 (1) ◽  
pp. 183-185 ◽  
Author(s):  
Elliot S. Gershon ◽  
Lynn R. Goldin ◽  
Juliet J. Guroff ◽  
Joel R. Hamovit
Keyword(s):  
Mental Health ◽  
Affective Disorders ◽  
Family Study

The Genetics of Hypodontia

1974 ◽  
Vol 53 (4) ◽  
pp. 781-785 ◽  
Author(s):  
Brian K. Suarez ◽  
M. Anne Spence
Keyword(s):  
Major Gene ◽  
Large Body ◽  
Family Data ◽  
Threshold Models ◽  
Gene Model ◽  
Polygenic Model ◽  
Multiple Threshold ◽  
Better Than

A large body of family data was analyzed to explain the genetics of hypodontia. Two multiple threshold models that were developed for quasicontinuous traits were used. The data fit the polygenic model much better than they fit the single major gene model.

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