The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons

Neuroscience ◽  
1999 ◽  
Vol 93 (1) ◽  
pp. 253-263 ◽  
Author(s):  
K. Kimpinski ◽  
S. Jelinski ◽  
K. Mearow
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sensory Neurons ◽  
Neurotrophic Factor ◽  
Neurite Growth ◽  
Brain Derived Neurotrophic Factor ◽  
Nerve Growth

scholarly journals Watching Neurons Hand Off Molecules

2002 ◽  
Vol 10 (1) ◽  
pp. 3-34
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Target Cells ◽  
Nerve Growth ◽  
Hand Off ◽  
Presynaptic Neurons

Since the discovery of nerve growth factor, it has been thought that neurotrophic factors are released or secreted from target cells. However, more recently it has been suggested that a specific neurotrophic factor known as brain-derived neurotrophic factor (BDNF) may reach target cells directly from pre-synaptic axons. It has not been known how these molecules get from the neuron in which they are produced to the target cells. Keigo Kohara, Akihiko Kitamura, Mieko Morishima, and Tadaharu Tsumoto have demonstrated that BDNF is transported anterogradely from presynaptic neurons to target neurons.

Sign in / Sign up

Export Citation Format

Share Document