Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial

2001 ◽  
Vol 108 (9) ◽  
pp. 952-959 ◽  
Author(s):  
G.J Hofmeyr ◽  
Z Alfirevic ◽  
B Matonhodze ◽  
P Brocklehurst ◽  
E Campbell ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Induction Of Labour ◽  
Oral Misoprostol

scholarly journals Induction of labour in pre-eclamptic women: a randomised trial comparing the Foley balloon catheter with oral misoprostol

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Hillary Bracken ◽  
Shuchita Mundle ◽  
Brian Faragher ◽  
Thomas Easterling ◽  
Alan Haycox ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Balloon Catheter ◽  
Induction Of Labour ◽  
Oral Misoprostol

scholarly journals The Induction with Foley OR Misoprostol (INFORM) Study dataset. A dataset of 602 women with hypertensive disease in pregnancy, in India, randomised to either Foley catheter or oral misoprostol for induction of labour

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shuchita Mundle ◽  
Hillary Bracken ◽  
Vaishali Khedikar ◽  
Jayashree Mulik ◽  
Brian Faragher ◽  
...  
Keyword(s):  
Low Income ◽  
Foley Catheter ◽  
Mode Of Delivery ◽  
Randomised Trial ◽  
Induction Of Labour ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Mortality And Morbidity ◽  
Oral Misoprostol ◽  
In Pregnancy

Abstract Objectives Induction of labour (IOL), or starting labour artificially, can be a lifesaving intervention for pregnant women and their babies, and rates are rising significantly globally. As rates increase, it becomes increasingly important to fully evaluate all available data, especially that from low income settings where the potential benefits and harms are greater. The goal of this paper is to describe the datasets collected as part of the Induction with Foley OR Misoprostol (INFORM) Study, a randomised trial comparing two of the recommended methods of cervical ripening for labour induction, oral misoprostol and Foley catheter, in women being induced for hypertension in pregnancy, at two sites in India during 2013–15. Data description This dataset includes comprehensive data on 602 women who underwent IOL for hypertensive disorders in pregnancy. Women were randomly assigned to cervical ripening with oral misoprostol or a transcervical Foley catheter in two government hospitals in India. The main dataset has 367 variables including monitoring during the induction of labour, medications administered, timing and mode of delivery, measures of neonatal morbidity and mortality, maternal mortality and morbidity, maternal satisfaction and health economic data. The dataset is anonymised and available on ReShare.

Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial

2001 ◽  
Vol 108 (9) ◽  
pp. 952-959 ◽  
Author(s):  
G.J. Hofmeyr ◽  
Z. Alfirevic ◽  
B. Matonhodze ◽  
P. Brocklehurst ◽  
E. Campbell ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Induction Of Labour ◽  
Oral Misoprostol

scholarly journals Comparison of vaginal and oral misoprostol, for the induction of labour in women with intra-uterine foetal death

2017 ◽  
Vol 6 (7) ◽  
pp. 2900
Author(s):  
Kala K. ◽  
Anupama V. Rani ◽  
Dharmavijaya M. N. ◽  
Umashankar K. M.
Keyword(s):  
Prostaglandin E1 ◽  
Post Partum ◽  
Induction Of Labour ◽  
Delivery Time ◽  
Foetal Death ◽  
Tertiary Institution ◽  
Oral Misoprostol ◽  
Significant Difference ◽  
Successful Induction ◽  
Vaginal Misoprostol

Background: Misoprostol is a prostaglandin E1 analogue, a methyl-ester of prostaglandin E1 additionally methylated at C-16. Misoprostol is an effective myometrial stimulant of pregnant uterus, selectively binding to prostanoid receptors. The objective of the study was to compare the efficacy of vaginal and oral misoprostol for the induction of labour in women with intra-uterine foetal death (IUFD).Methods: A prospective randomised clinical trial, comparing 50µg oral and 50µg vaginal misoprostol, six hourlies for a maximum of four doses for the induction of labour in women with IUFD. All patients with IUFD after 28 weeks without previous uterine surgeries, without contraindications for prostaglandins are included in the study. The study was conducted in the Department of Obstetrics and Gynecology MVJ Medical College and Research Hospital, Hoskote. Bangalore from June 2012 to June 2015. It is a tertiary institution serving predominantly rural population. The primary outcome measure was the induction to delivery time, secondary all complications were noted.Results: Twenty-five women were randomised to the vaginal route and twenty-five to the oral route. The induction to delivery time was longer with vaginal misoprostol 10.5±4.03 compared to oral misoprostol (9.58±4.9). There was no significant difference in the amount of misoprostol needed to achieve successful induction in the two groups. 3 patients needed oxytocin augmentation to complete the induction of labour. There were no cases of failed induction. The systemic side effects (shivering, diarrhoea, vomiting and pyrexia) were more common with oral misoprostol (44.5%) compared to vaginal misoprostol (20%).Conclusions: Oral misoprostol achieved successful induction of labour in women with IUFD in a shorter time than vaginal misoprostol. Both routes are equally effective in termination of pregnancy. Sublingual route is easy to administer, patient compliant, no need for internal examination, less chance of labour dysfunction, less chance of post-partum sepsis.

scholarly journals A comparative study of vaginal misoprostol versus oral misoprostol for induction of labour

2020 ◽  
Vol 9 (6) ◽  
pp. 2520
Author(s):  
Raj M. Mehta ◽  
Babulal S. Patel ◽  
Akshay C. Shah ◽  
Shashwat K. Jani ◽  
Vismay B. Patel ◽  
...  
Keyword(s):  
Adverse Events ◽  
Comparative Study ◽  
Mode Of Delivery ◽  
Induction Of Labour ◽  
Successful Outcome ◽  
Oral Misoprostol ◽  
Misoprostol Group ◽  
Group A ◽  
Vaginal Misoprostol ◽  
Group B

Background: Induction of labour defined as artificial initiation of uterine contractions before the onset of spontaneous labour, after the period of viability, by any methods. The successful outcome depends on the Bishop Score, maternal age and parity. Authors compared the most preferred two routes; vaginal and oral for induction and outcome, adverse events and side effects were noted.Methods: This was a prospective comparative study carried out at SVPIMSR, Ahmedabad, from January 2019 to June 2019, Gujarat, 100 patients who required induction were randomly divided in two groups- Group A received 25µg oral misoprostol, Group B - received 25µg vaginal misoprostol repeated 4 hourly up to maximum five doses in both groups. The induction to delivery interval, mode of delivery, maternal and neonatal outcome and complications were observed.Results: The mean induction to delivery interval was less in vaginal group than oral (18.7 hours in vaginal versus 22.4 hours in oral). Vaginal delivery and caesarean section rates were comparable in both groups. 60% patients in Group A required more than two doses as compared to 36% in Group B. No major complications or adverse events were observed.Conclusions: Both oral misoprostol in a dose of 25μg and vaginal misoprostol 25μg every four hours, to a maximum of five doses, have safety and efficacy for induction. With The vaginal route, delivery occurs in less time and few doses required as compared to oral.

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