80 Cataracts following bone marrow transplantation (BMT) conditioned with total body irradiation (TBI) for acute leukemia (AL) in complete remission (CR): A study of the European group for blood and marrow transplantation

1997 ◽  
Vol 39 (2) ◽  
pp. 175
Author(s):  
Y. Belkacémi ◽  
M. Labopin ◽  
J.P. Vernant ◽  
H.G. Prentice ◽  
A. Tichelli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Complete Remission ◽  
Acute Leukemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Blood And Marrow Transplantation ◽  
Total Body ◽  
European Group

scholarly journals Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987 Jun;69(6):1789]

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1015-1020 ◽  
Author(s):  
KG Blume ◽  
SJ Forman ◽  
MR O'Donnell ◽  
JH Doroshow ◽  
RA Krance ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Acute Leukemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Disease Free Survival ◽  
Hematologic Malignancies ◽  
High Dose ◽  
Pharmacokinetic Studies ◽  
Total Body

In a phase I/II study, 47 patients (median age, 24 years) with hematologic malignancies (33 patients with acute leukemia not in first remission and 14 patients with other advanced malignant hematologic disorders) were treated with total body irradiation and high doses of etoposide (VP16–213) followed by bone marrow transplantation. At the time of analysis, 21 patients were alive, and 19 of them were in continued complete remission for 101 days to greater than 40 months (median, 12 months). The actuarial disease-free survival rate of the 33 acute leukemia patients is 43% (2 SEM, 18%) and the actuarial relapse rate is 32% (2 SEM, 20%). Five of the 14 patients with the other hematologic malignancies are alive, and four of them continue to be free of disease for 8 to 27 months. Pharmacokinetic studies established a strong correlation between the administered drug doses and their plasma levels and also demonstrated complete drug clearance prior to marrow grafting. An etoposide dose of 60 mg/kg body weight was found to be the maximum tolerated dose. This new preparatory regimen was well tolerated and was not associated with specific acute or long-term regimen-related toxicities. Our data suggest that total body irradiation with high-dose etoposide presents a viable alternative to other preparatory regimens. The role of this novel combination remains to be defined by future prospective randomized trials.

Syngeneic Bone Marrow Transplantation in a Patient with Metastatic Neuroblastoma Refractory to Conventional Therapy

PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 573-574
Author(s):  
Wayne E. Spruce ◽  
Karl G. Blume ◽  
Owen B. Ellington ◽  
Gerhard M. Schmidt ◽  
Jaime Zusman
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Complete Remission ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Conventional Therapy ◽  
Conventional Chemotherapy ◽  
Total Body ◽  
Lethal Doses

A child with metastatic neuroblastoma refractory to conventional chemotherapy was treated with lethal doses of chemotherapy and total body irradiation followed by syngeneic bone marrow transplantation. A complete remission was achieved. However, the tumor recurred after six months, and the patient succumbed to disseminated neuroblastoma nine months after marrow grafting.

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