Evidence that nitric oxide production increases γ-amino butyric acid permeability of blood-brain barrier

2002 ◽  
Vol 57 (2) ◽  
pp. 231-236 ◽  
Author(s):  
N Shyamaladevi ◽  
A.R Jayakumar ◽  
R Sujatha ◽  
V Paul ◽  
E.H Subramanian
Keyword(s):  
Nitric Oxide ◽  
Blood Brain Barrier ◽  
Butyric Acid ◽  
Brain Barrier ◽  
Nitric Oxide Production ◽  
Amino Butyric Acid ◽  
Oxide Production ◽  
Blood Brain

Effects of Inhibition of Nitric Oxide Synthase on Blood-Brain Barrier Transport in Focal Cerebral Ischemia

Pharmacology ◽  
1994 ◽  
Vol 48 (6) ◽  
pp. 367-373 ◽  
Author(s):  
Oak Za Chi ◽  
Hwu Meei Wei ◽  
Arabinda K. Sinha ◽  
Harvey R. Weiss
Keyword(s):  
Nitric Oxide ◽  
Cerebral Ischemia ◽  
Nitric Oxide Synthase ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Oxide Synthase

Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide

1998 ◽  
Vol 5 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Takeshi Minami ◽  
Jiro Okazaki ◽  
Atsufumi Kawabata ◽  
Hideko Kawaki ◽  
Yuko Okazaki ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Tyrosine confounds oxidative electrochemical detection of nitric oxide

1998 ◽  
Vol 274 (5) ◽  
pp. H1698-H1704 ◽  
Author(s):  
R. Stingele ◽  
D. A. Wilson ◽  
R. J. Traystman ◽  
D. F. Hanley
Keyword(s):  
Nitric Oxide ◽  
Blood Brain Barrier ◽  
Electrochemical Detection ◽  
Concentration Gradient ◽  
Brain Barrier ◽  
Future Studies ◽  
Biologically Relevant ◽  
Blood Brain ◽  
Dog Brain ◽  
Order Of Magnitude

We report evidence that a porphyrinic microsensor for detection of nitric oxide (NO) also detects biologically relevant concentrations of tyrosine (Tyr) in dog brain. Tyr is oxidized by this sensor at the same potential as NO, and the sensitivity for NO and Tyr are of the same order of magnitude. The interference from Tyr is of importance because 1) Tyr is abundant and 2) there is a concentration gradient of Tyr across the blood-brain barrier that can lead to unpredictable results if disturbed by ischemia or hypoxia. The knowledge of this interference is important for the interpretation of results obtained with this sensor and for the design of future studies.

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