Compositional pressure and translational selection determine codon usage in the extremely GC-poor unicellular eukaryote Entamoeba histolytica

Gene ◽  
2000 ◽  
Vol 242 (1-2) ◽  
pp. 307-311 ◽  
Author(s):  
Héctor Romero ◽  
Alejandro Zavala ◽  
Héctor Musto
Parasitology ◽  
2004 ◽  
Vol 128 (3) ◽  
pp. 245-251 ◽  
Author(s):  
L. PEIXOTO ◽  
V. FERNÁNDEZ ◽  
H. MUSTO

The usage of alternative synonymous codons in the completely sequenced, extremely A+T-rich parasitePlasmodium falciparumwas studied. Confirming previous studies obtained with less than 3% of the total genes recently described, we found that A- and U-ending triplets predominate but translational selection increases the frequency of a subset of codons in highly expressed genes. However, some new results come from the analysis of the complete sequence. First, there is more variation in GC3 than previously described; second, the effect of natural selection acting at the level of translation has been analysed with real expression data at 4 different stages and third, we found that highly expressed proteins increment the frequency of energetically less expensive amino acids. The implications of these results are discussed.


Gene ◽  
2012 ◽  
Vol 506 (1) ◽  
pp. 98-105 ◽  
Author(s):  
Andrés Iriarte ◽  
Manuel Sanguinetti ◽  
Tamara Fernández-Calero ◽  
Hugo Naya ◽  
Ana Ramón ◽  
...  

1992 ◽  
Vol 22 (3) ◽  
pp. 381-383 ◽  
Author(s):  
Shobha Char ◽  
Michael J.G. Farthing

1994 ◽  
Vol 22 (13) ◽  
pp. 2437-2446 ◽  
Author(s):  
Michele Stenico ◽  
Andrew T. Lloyd ◽  
Paul M. Sharp

Gene ◽  
2003 ◽  
Vol 320 ◽  
pp. 109-116 ◽  
Author(s):  
Lucı́a Peixoto ◽  
Alejandro Zavala ◽  
Héctor Romero ◽  
Héctor Musto

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