FRI-383-Role of traditional cardiovascular risk factors in predicting long term survival after liver transplantation

Background and Purpose: Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovascular risk factors on 5-year mortality, and analyzed time trend in 5-year mortality in ICH patients over 2 decades. Methods: We included 219 participants from the population-based Tromsø Study, who after the baseline participation had a first-ever ICH between 1994 to 2013 and 1095 age- and sex-matched participants without ICH. Cumulative survival was presented using the Kaplan-Meier method. Hazard ratios (HRs) for mortality and for the association between cardiovascular risk factors and 5-year mortality in 30-day survivors were estimated by stratified Cox proportional hazards models. Trend in 5-year mortality was assessed by logistic regression. Results: Risk of death during follow-up (median time, 4.8 years) was increased in the ICH group compared with controls (HR, 1.62 [95% CI, 1.27–2.06]). Cardiovascular disease was the leading cause of death, with a higher proportion in ICH patients (22.9% versus 9.0%; P <0.001). Smoking increased the risk of 5-year mortality in cases and controls (HR, 1.59 [95% CI, 1.15–2.19]), whereas serum cholesterol was associated with 5-year mortality in cases only (HR, 1.39 [95% CI, 1.04–1.86]). Use of anticoagulants at ICH onset increased the risk of death (HR, 2.09 [95% CI, 1.09–4.00]). There was no difference according to ICH location (HR, 1.15 [95% CI, 0.56–2.37]). Five-year mortality did not change during the study period (odds ratio per calendar year, 1.01 [95% CI, 0.93–1.09]). Conclusions: Survival rates were significantly lower in cases than in controls, driven by a 2-fold increased risk of cardiovascular death. Smoking, serum cholesterol, and use of anticoagulant drugs were associated with increased risk of death in ICH patients. Five-year mortality rates in ICH patients remained stable over time.

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P2540Sex-specific differences in the clinical presentation, surgical complications, and course of chronic thromboembolic pulmonary hypertension

European Heart Journal ◽

10.1093/eurheartj/ehz748.0868 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

S Barco ◽

F A Klok ◽

S V Konstantinides ◽

P Dartevelle ◽

E Fadel ◽

...

Keyword(s):

Risk Factors ◽

Pulmonary Hypertension ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Clinical Presentation ◽

Chronic Thromboembolic Pulmonary Hypertension ◽

Lower Prevalence ◽

Term Survival ◽

Thromboembolic Pulmonary Hypertension

Abstract Background Women are more susceptible to develop several forms of pulmonary hypertension, but they may have better survival rates than men. Sparse data are available concerning sex-specific differences in chronic thromboembolic pulmonary hypertension (CTEPH). Purpose and methods We investigated sex-specific differences in the clinical presentation of CTEPH, functional parameters, exposure to pulmonary endarterectomy (PEA), and survival. Results Women constituted half of the study population (N=679 treatment-naïve patients from the European CTEPH registry) and were characterized by a lower prevalence of some cardiovascular risk factors (e.g. prior acute coronary syndrome, smoking habit, chronic obstructive pulmonary disease), but more prevalent obesity, cancer, and thyroid diseases. Median age was 62 (IQR 50–73) years in women and 63 (IQR 53–70) in men. Women underwent PEA less often than men (54% vs 65%; Figure 1, Panel A) and were exposed to fewer additional cardiac procedures, notably coronary artery bypass graft surgery (0.5% vs. 9.5%). The prevalence of specific reasons for not being operated, including the patient's refusal and the proportion of proximal vs. distal lesions, did not differ between sexes. A total of 57 (17.0%) deaths in women and 70 (20.7%) in men were recorded over long-term follow-up. Female sex was positively associated with long-term survival (adjusted Hazard Ratio 0.66; 95% Confidence Interval 0.46–0.94). Short-term mortality was identical in the two groups (Figure 1, Panel B). Conclusions Women with CTEPH had a lower prevalence of cardiovascular risk factors and underwent PEA less frequently than men, who, in turn, were more often exposed to additional major cardiac surgery procedures. Women had more favorable long-term survival. Acknowledgement/Funding The CTEPH registry is supported by a research grant from Actelion Pharmaceuticals Ltd.

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The Pre-Transplant Profile of Cardiovascular Risk Factors and Its Impact on Long-Term Mortality After Liver Transplantation

Annals of Transplantation ◽

10.12659/aot.908771 ◽

2018 ◽

Vol 23 ◽

pp. 591-597 ◽

Cited By ~ 4

Author(s):

Renata Główczyńska ◽

Michalina Galas ◽

Anna Witkowska ◽

Urszula Ołdakowska-Jedynak ◽

Joanna Raszeja-Wyszomirska ◽

...

Keyword(s):

Risk Factors ◽

Liver Transplantation ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Long Term Mortality

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Cardiovascular Risk Factors and Cardiac Disorders in Long-Term Survivors of Pediatric Liver Transplantation: Presidential Poster

The American Journal of Gastroenterology ◽

10.1038/ajg.2014.284 ◽

2014 ◽

Vol 109 ◽

pp. S593 ◽

Cited By ~ 1

Author(s):

Shankar Baskar ◽

Peggy George ◽

Bijan Eghtesad ◽

Vera Hupertz ◽

Aziz Peter ◽

...

Keyword(s):

Risk Factors ◽

Liver Transplantation ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Pediatric Liver Transplantation ◽

Pediatric Liver ◽

Cardiac Disorders ◽

Long Term Survivors

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355 – Treatment of Cardiovascular Risk Factors Improves Long Term Outcome Post Liver Transplantation

Gastroenterology ◽

10.1016/s0016-5085(19)39960-3 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-1193-S-1194

Author(s):

Saad A. Alghamdi ◽

Osama Altayar ◽

Alexis M. Bayudan ◽

Jaquelyn Fleckenstein ◽

Mauricio Lisker-Melman ◽

...

Keyword(s):

Risk Factors ◽

Liver Transplantation ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Term Outcome ◽

Long Term Outcome

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Surgical outcomes of advanced NSCLC (stage IIIB and IV).

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e17523 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e17523-e17523

Author(s):

Jae Hyun Kim ◽

Jong Ho Park ◽

Hae Won Lee ◽

Jin Wook Hwang ◽

Moon Chul Kang ◽

...

Keyword(s):

Risk Factors ◽

Surgical Resection ◽

Stage Iv ◽

Stage Iiib ◽

Cancer Center ◽

Incomplete Resection ◽

Term Survival ◽

Long Term Survival

e17523 Background: The role of surgery in the stage IIIB or IV NSCLC (AJCC 6th edition) patients is has been controversial. Now in AJCC 7th edition, the operable T4 and M1 stages were regrouped to IIIA. We analyzed the clinical outcome of the surgical resection for the patients with operable NSCLC of stage IIIB or IV in AJCC 6th edition to evaluate the role of surgery in this group. Methods: From January 1990 to Desember 2009, the 102 patients with stage IIIB(T4) NSCLC and the 36 patients with stage IV (separate tumor in ipsilateral different lobe) NSCLC had been operated in Korean cancer center. We analyzed the long term survival and the risk factors for long term survival of the 138 patient retrospectively. Results: 59 (42.7%) patients had the invasion of major mediastinal organ, and 43 (31.1%) had separate tumor nodules in ipsilateral different lobe, and 36 (26%) had satellite nodules in same lobe. N0 stage was identified in 42 (30.4%) patients, N1 stage in 29 (21%), and N2 stage in 67 (48.6%). Lobectomy was performed in 56 (40.5%) patients, bilobctomy in 14 (10.1%) and pneumonectomy in 68 (49.2%). Complete resection was achieved in 123 (89.1%) and operation mortality rate was 6.5% (9/138 patients). Median survival was 34 months and 5-year and 10-year survival rate was 34.6% and 21.9% respectively. Recurrence, surgery alone, N2 stage, incomplete resection were risk factors of long term survival in multivariate analysis. Conclusions: Although the role of a surgery in the stage IIIB, IV NSCLC patients is very limited, the long term outcomes of surgical resection of them are tolerable in Korean cancer center. So we thought the shifting of stage of the group with operable stage IIIB or IV NSCLC to IIIA is appropriate.

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