Blast lung injury: Clinical manifestations, treatment, and outcome

2007 ◽  
Vol 2007 ◽  
pp. 28-29
Author(s):  
D.J. Dries
Keyword(s):  
Lung Injury ◽  
Clinical Manifestations ◽  
Blast Lung Injury

Blast lung injury: clinical manifestations, treatment, and outcome

2005 ◽  
Vol 190 (6) ◽  
pp. 945-950 ◽  
Author(s):  
Vered Avidan ◽  
Moshe Hersch ◽  
Yaron Armon ◽  
Ram Spira ◽  
Dvora Aharoni ◽  
...  
Keyword(s):  
Lung Injury ◽  
Clinical Manifestations ◽  
Blast Lung Injury

scholarly journals NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves

2021 ◽  
Author(s):  
Hong Wang ◽  
Wenjuan Zhang ◽  
Jinren Liu ◽  
Junhong Gao ◽  
Le Fang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Shock Waves ◽  
Time Dependent ◽  
Inflammatory Factors ◽  
Control Group ◽  
Dependent Manner ◽  
Total Antioxidant ◽  
Blast Lung Injury ◽  
And Oxidative Stress

Abstract Blast lung injury (BLI) is the major cause of death in explosion-derived shock waves; however, the mechanisms of BLI are not well understood. To identify the time-dependent manner of BLI, a model of lung injury of rats induced by shock waves was established by a fuel air explosive. The model was evaluated by hematoxylin and eosin staining and pathological score. The inflammation and oxidative stress of lung injury were also investigated. The pathological scores of rats’ lung injury at 2 h, 24 h, 3 days, and 7 days post-blast were 9.75±2.96, 13.00±1.85, 8.50±1.51, and 4.00±1.41, respectively, which were significantly increased compared with those in the control group (1.13±0.64; P<0.05). The respiratory frequency and pause were increased significantly, while minute expiratory volume, inspiratory time, and inspiratory peak flow rate were decreased in a time-dependent manner at 2 and 24 h post-blast compared with those in the control group. In addition, the expressions of inflammatory factors such as interleukin (IL)-6, IL-8, FosB, and NF-κB were increased significantly at 2 h and peaked at 24 h, which gradually decreased after 3 days and returned to normal in 2 weeks. The levels of total antioxidant capacity, total superoxide dismutase, and glutathione peroxidase were significantly decreased 24 h after the shock wave blast. Conversely, the malondialdehyde level reached the peak at 24 h. These results indicated that inflammatory and oxidative stress induced by shock waves changed significantly in a time-dependent manner, which may be the important factors and novel therapeutic targets for the treatment of BLI.

scholarly journals Nebulised recombinant activated factor VII (rFVIIa) does not attenuate the haemorrhagic effects of blast lung injury

2018 ◽  
Vol 165 (1) ◽  
pp. 51-56
Author(s):  
Jason E Smith ◽  
S Watts ◽  
A M Spear ◽  
C Wilson ◽  
E Kirkman
Keyword(s):  
Lung Injury ◽  
Electron Paramagnetic Resonance Spectroscopy ◽  
Rabbit Model ◽  
Factor Vii ◽  
Alveolar Haemorrhage ◽  
Systemic Absorption ◽  
Resonance Spectroscopy ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii ◽  
Blast Lung Injury

IntroductionPrimary blast lung injury causes intrapulmonary haemorrhage. A number of case reports have suggested the efficacy of recombinant activated factor VII (rFVIIa) in the treatment of diffuse alveolar haemorrhage from a range of medical causes, but its efficacy in blast lung is unknown. The aim of this study was to investigate whether nebulised rFVIIa attenuates the haemorrhagic effects of blast lung injury in an animal model.MethodsTerminally anaesthetised rabbits subjected to blast lung injury were randomised to receive either rFVIIa or placebo via a nebuliser. The primary outcome was the level of blood iron–transferrin complex, a marker of the extent of blast lung injury, analysed using low temperature electron paramagnetic resonance spectroscopy.ResultsBlast exposure led to a significant fall in iron-bound transferrin in both groups of animals (p<0.001), which remained depressed during the study. There were no significant differences in iron–transferrin between the rFVIIa and placebo treatment groups over the duration of the study (p=0.081), and there was no trend towards elevated iron–transferrin in the rFVIIa-treated group once drug treatment had started. There was suggestive evidence of systemic absorption of rFVIIa given via the inhaled route.ConclusionA single dose of nebulised rFVIIa did not attenuate pulmonary haemorrhage in a rabbit model of blast lung injury. As there was some evidence of systemic absorption, the inhaled route does not avoid the concern about potential thromboembolic complications from administration of rFVIIa.

A model for predicting primary blast lung injury

2012 ◽  
Vol 73 (5) ◽  
pp. 1121-1129 ◽  
Author(s):  
Lisa N. MacFadden ◽  
Philemon C. Chan ◽  
Kevin H.-H. Ho ◽  
James H. Stuhmiller
Keyword(s):  
Lung Injury ◽  
Primary Blast ◽  
Blast Lung Injury

Blast Lung Injury

2012 ◽  
pp. 342-342
Author(s):  
Vikas P. Chaubey ◽  
Kevin B. Laupland ◽  
Christopher B. Colwell ◽  
Gina Soriya ◽  
Shelden Magder ◽  
...  
Keyword(s):  
Lung Injury ◽  
Blast Lung Injury

Primary Blast Lung Injury

2020 ◽  
pp. 23-38
Author(s):  
Linghua Peng ◽  
Guanghua Guo ◽  
Jianxin Jiang
Keyword(s):  
Lung Injury ◽  
Primary Blast ◽  
Blast Lung Injury

Comparison of blast lung injury in infant and adult rabbits

2019 ◽  
Vol 55 (2) ◽  
pp. 474-483 ◽  
Author(s):  
Ao Yang ◽  
Hanzi Cai ◽  
Yi Liang ◽  
Danfeng Yuan ◽  
Wei Dai ◽  
...  
Keyword(s):  
Lung Injury ◽  
Blast Lung Injury

scholarly journals Early Peritoneal Dialysis Ameliorates Blast Lung Injury by Alleviating Pulmonary Edema and Inflammation

Shock ◽  
2020 ◽  
Vol 53 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Kehong Chen ◽  
Jie Yang ◽  
Fei Xiao ◽  
Jia Chen ◽  
Wei Hu ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Lung Injury ◽  
Pulmonary Edema ◽  
Blast Lung Injury
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