scholarly journals ABSOLUTE CORONARY BLOOD FLOW AND CORONARY FLOW RESERVE ASSESSED BY GATED SPECT WITH CADMIUM-ZINC-TELLURIDE DETECTORS: A DIRECT COMPARISON WITH 13N-AMMONIA PET

2013 ◽  
Vol 61 (10) ◽  
pp. E1005 ◽  
Author(s):  
Aju P. Pazhenkottil ◽  
René Nkoulou ◽  
Silke Kuest ◽  
Jelena Ghadri ◽  
Michael Fiechter ◽  
...  
2018 ◽  
Vol 71 (11) ◽  
pp. A1503
Author(s):  
Gustavo Daquarti ◽  
Alejandro H. Meretta ◽  
Daniel Rosa ◽  
Eugenia Aguirre ◽  
Mariana Corneli ◽  
...  

1992 ◽  
Vol 123 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Shinsuke Nanto ◽  
Kazuhisa Kodama ◽  
Masatsugu Hori ◽  
Masayoshi Mishima ◽  
Atsushi Hirayama ◽  
...  

2011 ◽  
Vol 301 (6) ◽  
pp. H2279-H2284 ◽  
Author(s):  
Andrea Picchi ◽  
Ugo Limbruno ◽  
Marta Focardi ◽  
Bernardo Cortese ◽  
Andrea Micheli ◽  
...  

A reduced coronary flow reserve (CFR) has been demonstrated in diabetes, but the underlying mechanisms are unknown. We assessed thermodilution-derived CFR after 5-min intravenous adenosine infusion through a pressure-temperature sensor-tipped wire in 30 coronary arteries without significant lumen reduction in 30 patients: 13 with and 17 without a history of diabetes. We determined CFR as the ratio of basal and hyperemic mean transit times (Tmn); fractional flow reserve (FFR) as the ratio of distal and proximal pressures at maximal hyperemia to exclude local macrovascular disease; and an index of microvascular resistance (IMR) as the distal coronary pressure at maximal hyperemia divided by the inverse of the hyperemic Tmn. We also assessed insulin resistance by the homeostasis model assessment (HOMA) index. FFR was normal in all investigated arteries. CFR was significantly lower in diabetic vs. nondiabetic patients [median (interquartile range): 2.2 (1.4–3.2) vs. 4.1 (2.7–4.4); P = 0.02]. Basal Tmn was lower in diabetic vs. nondiabetic subjects [median (interquartile range): 0.53 (0.25–0.71) vs. 0.64 (0.50–1.17); P = 0.04], while hyperemic Tmn and IMR were similar. We found significant correlations at linear regression analysis between logCFR and the HOMA index ( r2 = 0.35; P = 0.0005) and between basal Tmn and the HOMA index ( r2 = 0.44; P < 0.0001). In conclusion, compared with nondiabetic subjects, CFR is lower in patients with diabetes and epicardial coronary arteries free of severe stenosis, because of increased basal coronary flow, while hyperemic coronary flow is similar. Basal coronary flow relates to insulin resistance, suggesting a key role of cellular metabolism in the regulation of coronary blood flow.


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