scholarly journals Multislice magnetic resonance imaging of myocardial perfusion using Gd-HP-DO3A on a conventional clinical scanner: A comparison study with radionuclide perfusion imaging in a general patient population

1996 ◽  
Vol 27 (2) ◽  
pp. 270
Author(s):  
Edward G. Walsh ◽  
Mark A. Lawson ◽  
Mark Doyle ◽  
Gerald M. Pohost
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
Patient Population ◽  
Comparison Study ◽  
Resonance Imaging ◽  
Clinical Scanner

scholarly journals Molecular Mechanisms of Adenosine Stress T1 Mapping

2021 ◽  
Author(s):  
Soham A. Shah ◽  
Claire E. Reagan ◽  
Brent A. French ◽  
Frederick H. Epstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
T1 Mapping ◽  
Myocardial Perfusion Reserve ◽  
Adenosine Stress ◽  
Resonance Imaging ◽  
Perfusion Reserve

Background: Adenosine stress T1 mapping is an emerging magnetic resonance imaging method to investigate coronary vascular function and myocardial ischemia without application of a contrast agent. Using gene-modified mice and 2 vasodilators, we elucidated and compared the mechanisms of adenosine myocardial perfusion imaging and adenosine T1 mapping. Methods: Wild-type (WT), A 2A AR −/− (adenosine A 2A receptor knockout), A 2B AR −/− (adenosine A 2B receptor knockout), A 3 AR −/− (adenosine A 3 receptor knockout), and eNOS −/− (endothelial nitric oxide synthase knockout) mice underwent rest and stress perfusion magnetic resonance imaging (n=8) and T1 mapping (n=10) using either adenosine, regadenoson (a selective A 2A AR agonist), or saline. Myocardial blood flow and T1 were computed from perfusion imaging and T1 mapping, respectively, at rest and stress to assess myocardial perfusion reserve and T1 reactivity (ΔT1). Changes in heart rate for each stress agent were also calculated. Two-way ANOVA was used to detect differences in each parameter between the different groups of mice. Results: Myocardial perfusion reserve was significantly reduced only in A 2A AR −/− compared to WT mice using adenosine (1.06±0.16 versus 2.03±0.52, P <0.05) and regadenoson (0.98±026 versus 2.13±0.75, P <0.05). In contrast, adenosine ΔT1 was reduced compared with WT mice (3.88±1.58) in both A 2A AR −/− (1.63±1.32, P <0.05) and A 2B AR −/− (1.55±1.35, P <0.05). Furthermore, adenosine ΔT1 was halved in eNOS −/− (1.76±1.46, P <0.05) versus WT mice. Regadenoson ΔT1 was approximately half of adenosine ΔT1 in WT mice (1.97±1.50, P <0.05), and additionally, it was significantly reduced in eNOS −/− mice (−0.22±1.46, P <0.05). Lastly, changes in heart rate was 2× greater using regadenoson versus adenosine in all groups except A 2A AR −/− , where heart rate remained constant. Conclusions: The major findings are that (1) although adenosine myocardial perfusion reserve is mediated through the A 2A receptor, adenosine ΔT1 is mediated through the A 2A and A 2B receptors, (2) adenosine myocardial perfusion reserve is endothelial independent while adenosine ΔT1 is partially endothelial dependent, and (3) ΔT1 mediated through the A 2A receptor is endothelial dependent while ΔT1 mediated through the A 2B receptor is endothelial independent.

scholarly journals Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent

Circulation ◽  
2009 ◽  
Vol 119 (13) ◽  
pp. 1768-1775 ◽  
Author(s):  
Elmar Spuentrup ◽  
Karl M. Ruhl ◽  
Rene M. Botnar ◽  
Andrea J. Wiethoff ◽  
Alexandra Buhl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Contrast Agent ◽  
Resonance Imaging

Stress Cardiac Magnetic Resonance Imaging

2018 ◽  
pp. 335-343
Author(s):  
Yeonyee E. Yoon ◽  
L. Samuel Wann
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Cardiac Magnetic Resonance Imaging ◽  
Wall Motion ◽  
Scar Tissue ◽  
Resonance Imaging ◽  
Stress Cardiac Magnetic Resonance ◽  
Myocardial Thickening

The chapter Stress Cardiac Magnetic Resonance Imaging reviews how cardiovascular magnetic resonance imaging (CMR) has become a gold standard for evaluating stress induced wall motion abnormalities based on regional endocardial excursion and myocardial thickening. The high spatial and temporal resolution of CMR without limitations imposed by body habitus and acoustic windows allows outstanding visualization of myocardial function. CMR can also be combined with vasodilator stress to perform dynamic first-pass myocardial perfusion imaging. The addition of late gadolinium enhancement allows the accurate of nonviable scar tissue in combination with wall motion and myocardial perfusion assessment. Case studies highlight the opportunity provided by stress CMR.

scholarly journals Clinical experience of magnetic resonance imaging in patients with cardiac pacing devices: unrestricted patient population

2019 ◽  
Vol 60 (11) ◽  
pp. 1414-1421 ◽  
Author(s):  
Aino-Maija Vuorinen ◽  
Sami Pakarinen ◽  
Ilkka Jaakkola ◽  
Miia Holmström ◽  
Sari Kivistö ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Experience ◽  
Patient Population ◽  
Cardiac Pacing ◽  
Resonance Imaging
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