Beneficial Effect of Estrogen Therapy on Fibrinolysis is Independent of Changes in Low-Density Lipoprotein Levels

Ghrelin is a novel peptide hormone that has GH releasing activity and also other endocrine and metabolic functions. The purpose of this study was to investigate the effects of estrogen replacement therapy on plasma active ghrelin levels in 64 hysterectomized postmenopausal women receiving peroral estrogen (PE) or transdermal estrogen therapy for 6 months. Active ghrelin was measured using commercial RIA. Estrogen therapy increased plasma active ghrelin from 479 ± 118 to 521 ± 123 pg/ml (P = 0.002) among all the study subjects. PE therapy increased plasma ghrelin levels from 465 ± 99 to 536 ± 104 pg/ml (P = 0.001). Transdermal estrogen therapy did not increase plasma ghrelin levels significantly (from 491 ± 132 to 509 ± 138 pg/ml; P = 0.332). The relative changes in plasma ghrelin levels were associated with the relative changes in serum estradiol concentrations (r = 0.299; P = 0.017). During the estrogen therapy, negative associations were found between plasma active ghrelin levels and several plasma lipids (total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, total triglycerides, and very low-density lipoprotein triglycerides). As a conclusion, estrogen replacement therapy increased active plasma ghrelin levels, particularly PE therapy. Additional studies are needed to determine the possible underlying mechanisms.

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Beneficial effect of low-density lipoprotein apheresis (LDL-A) on refractory nephrotic syndrome (NS) due to focal glomerulosclerois (FGS)

Clinical Nephrology ◽

10.5414/cnp67341 ◽

2007 ◽

Vol 67 (06) ◽

pp. 341-345 ◽

Cited By ~ 30

Author(s):

E. Muso ◽

M. Mune ◽

N. Yorioka ◽

Y. Nishizawa ◽

T. Hirano ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Beneficial Effect ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Apheresis ◽

Refractory Nephrotic Syndrome

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Beneficial effect of ghee consumption over mustard oil on lipid profile: A study in North Indian adult population

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2017-0101 ◽

2018 ◽

Vol 15 (3) ◽

Cited By ~ 1

Author(s):

Hanjabam Barun Sharma ◽

Soniya Vyas ◽

Jayant Kumar ◽

Soumen Manna

Keyword(s):

Beneficial Effect ◽

Lipid Profile ◽

Disease Risk ◽

Adult Population ◽

Cardiovascular Disease Risk ◽

Low Density Lipoprotein ◽

Saturated Fat ◽

Density Lipoprotein ◽

Mustard Oil ◽

Low Density

AbstractBackgroundGhee (G) is attributed with numerous health benefits in Ayurveda. However, due to the high saturated fat content, it has been predicted to increase the cardiovascular disease risk. Hence, the current study was performed to evaluate the effect of G consumption as compared to mustard oil (MO) on lipid profile.MethodsTwo hundred (100 males) apparently healthy adults (≥40 years) were randomly selected out of the total individuals interviewed in a house-to-house survey. They were divided into three groups based on G and MO consumption: (A) MO >1 L/month, G<0.5 kg/month; (B) MO 1–0.5 L/month, G 1.25–0.5 kg/month; and (C) MO <0.5–0.2 L/month, G>1.25 kg/month. Serum lipid parameters were compared among the groups.ResultsGroup C had the significantly lowest triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), TC/HDL and LDL/HDL and highest high-density lipoprotein (HDL). A similar finding was found when analysis was done separetely for male and female.ConclusionsA favorable lipid profile might suggest a possible beneficial effect of predominantly G consumption over MO.

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