Septal pacing in patients with dual chamber pacemakers and atrio-ventricular (AV) conduction malfunction, but without structural heart muscle impairment, is not worse than own AV conduction. Optimized AV delay in patients with first degree AV block and PQ interval > 220 ms may be better than preserving own contraction with pathologic atrio-ventricular delay, leading to asynchrony, ventricle remodeling and relaxation disorders.