Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity

2008 ◽  
Vol 2008 ◽  
pp. 29-30
Author(s):  
D.A. Katzka
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Irritable Bowel

scholarly journals Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Fong Wong ◽  
Anthony C. Rodrigues ◽  
Christopher D. King ◽  
Joseph L. Riley ◽  
Siegfried Schmidt ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Thermal Hyperalgesia ◽  
Thermal Stimulation ◽  
Thermal Pain ◽  
Pain Ratings ◽  
Irritable Bowel ◽  
Thermal Pain Sensitivity ◽  
Pain Patients ◽  
Skin Temperatures

This study evaluated relationships between irritable bowel syndrome (IBS) pain, sympathetic dysregulation, and thermal pain sensitivity. Eight female patients with diarrhea-predominant IBS and ten healthy female controls were tested for sensitivity to thermal stimulation of the left palm. A new method of response-dependent thermal stimulation was used to maintain pain intensity at a predetermined level (35%) by adjusting thermal stimulus intensity as a function of pain ratings. Clinical pain levels were assessed prior to each testing session. Skin temperatures were recorded before and after pain sensitivity testing. The temperature of palmar skin dropped (1.5) when the corresponding location on the opposite hand of control subjects was subjected to prolonged thermal stimulation, but this response was absent for IBS pain patients. The patients also required significantly lower stimulus temperatures than controls to maintain a 35% pain rating. Baseline skin temperatures of patients were significantly correlated with thermode temperatures required to maintain 35% pain ratings. IBS pain intensity was not significantly correlated with skin temperature or pain sensitivity. The method of response-dependent stimulation revealed thermal hyperalgesia and increased sympathetic tone for chronic pain patients, relative to controls. Similarly, a significant correlation between resting skin temperatures and thermal pain sensitivity for IBS but not control subjects indicates that tonic sympathetic activation and a thermal hyperalgesia were generated by the chronic presence of visceral pain. However, lack of a significant relationship between sympathetic tone and ratings of IBS pain casts doubt on propositions that the magnitude of IBS pain is determined by psychological stress.

scholarly journals Relationships between psychological state, abuse, somatization and visceral pain sensitivity in irritable bowel syndrome

2018 ◽  
Vol 6 (2) ◽  
pp. 300-309 ◽  
Author(s):  
Cecilia Grinsvall ◽  
Hans Törnblom ◽  
Jan Tack ◽  
Lukas Van Oudenhove ◽  
Magnus Simrén
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Visceral Pain ◽  
Psychological State ◽  
Irritable Bowel

scholarly journals Association between pain sensitivity and gray matter properties in the sensorimotor network in women with irritable bowel syndrome

2020 ◽  
Author(s):  
Cecilia Grinsvall ◽  
Hyo Jin Ryu ◽  
Lukas Van Oudenhove ◽  
Jennifer S. Labus ◽  
Arpana Gupta ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gray Matter ◽  
Pain Sensitivity ◽  
Sensorimotor Network ◽  
Irritable Bowel

Sa1441 Do Protease Inhibitors Influence Visceral Pain Sensitivity in Patients With Irritable Bowel Syndrome?

2012 ◽  
Vol 142 (5) ◽  
pp. S-306
Author(s):  
Motoyori Kanazawa ◽  
Joe Morishita ◽  
Yukari Tanaka ◽  
Kyoko Inooka ◽  
Michiko Kano ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Protease Inhibitors ◽  
Pain Sensitivity ◽  
Visceral Pain ◽  
Irritable Bowel

scholarly journals Conditioned Pain Modulation in Women With Irritable Bowel Syndrome

2014 ◽  
Vol 16 (4) ◽  
pp. 368-377 ◽  
Author(s):  
Monica E. Jarrett ◽  
Robert J. Shulman ◽  
Kevin C. Cain ◽  
Wimon Deechakawan ◽  
Lynne T. Smith ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychological Distress ◽  
Salivary Cortisol ◽  
Pain Sensitivity ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Somatic Pain ◽  
Before And After ◽  
Cortisol Levels ◽  
Irritable Bowel

Evidence suggests that patients with irritable bowel syndrome (IBS) are more vigilant to pain-associated stimuli. The aims of this study were to compare women with IBS ( n = 20) to healthy control (HC, n = 20) women on pain sensitivity, conditioned pain modulation (CPM) efficiency, and salivary cortisol levels before and after the CPM test and to examine the relationship of CPM efficiency with gastrointestinal pain, somatic pain, psychological distress symptoms, and salivary cortisol levels in each group. Women, aged 20–42 years, gave consent, completed questionnaires, and kept a symptom diary for 2 weeks. CPM efficiency was tested with a heat test stimulus and cold water condition stimulus in a laboratory between 8 and 10 a.m. on a follicular phase day. Salivary cortisol samples were collected just before and after the experimental testing. Compared to the HC group, women with IBS reported more days with gastrointestinal and somatic pain/discomfort, psychological distress, fatigue, and feeling stressed. During the CPM baseline testing, women with IBS reported greater pain sensitivity compared to the HC group. There was no significant group difference in salivary cortisol levels nor in CPM efficiency, though a post-hoc analysis showed a higher prevalence of impaired CPM efficiency among IBS subjects with more severe lower-GI symptoms. In the IBS group, reduced CPM efficiency was associated with daily abdominal pain/discomfort and psychological distress. Overall, women with IBS exhibited an increased sensitivity to thermal stimuli. Impaired CPM was present in a subset of women with IBS.

Tu1810 Distinct Subtypes of Irritable Bowel Syndrome Are Defined by Psychological Symptoms, Visceral Pain Sensitivity, Stool Consistency, and Motility

2016 ◽  
Vol 150 (4) ◽  
pp. S954-S955
Author(s):  
Miranda A. van Tilburg ◽  
Magnus Simren ◽  
Olafur S. Palsson ◽  
Hans Törnblom ◽  
William E. Whitehead
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Visceral Pain ◽  
Psychological Symptoms ◽  
Stool Consistency ◽  
Irritable Bowel
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