THE PHYSIOLOGIC BASIS OF CONTINUOUS PASSIVE MOTION FOR ARTICULAR CARTILAGE HEALING AND REGENERATION

Hand Clinics ◽  
1994 ◽  
Vol 10 (2) ◽  
pp. 211-219
Author(s):  
Robert B. Salter
Author(s):  
Xiang Gu ◽  
Daniel Leong ◽  
Rashal Mahammud ◽  
Yong Hui Li ◽  
Hui Bin Sun ◽  
...  

Joint diseases are common causes of disability worldwide. Physical activity and weight bearing conditions play an important role in the regulation of joint homeostasis throughout life. The parametric characterization of deleterious and beneficial joint loading regimens influencing the homeostasis of articular cartilage is of great interest from both a basic research and clinical practice point of view. The development of in vivo animal models is critical to investigate the underlying mechanisms mediating the biological response of articular joints to external mechanical stimuli. For this purpose, the design of a device capable of accurately control the joint motion and loading in a small animal is needed. In the present work, an assisted motion system was conceived to perform continuous passive motion (CPM) and continuous loaded motion (CLM) on the knee joint of a small animal in vivo. A major purpose of this system is the study of the inflammatory and anti-inflammatory response of cartilage under several biomechanical environments. Therefore, a key design criterion was to avoid any invasive intervention (i.e. intraskeletal fixators) that may produce an intrinsic inflammatory response and then obscure/mislead the assessment of the biological markers of interest. Other important design criteria include real time control of the knee joint position, angular displacement, cyclic motion frequency and custom load magnitude applied in the axial direction along the tibia.


Cartilage ◽  
2010 ◽  
Vol 1 (4) ◽  
pp. 276-286 ◽  
Author(s):  
Jennifer S. Howard ◽  
Carl G. Mattacola ◽  
Spencer E. Romine ◽  
Christian Lattermann

1994 ◽  
Vol &NA; (304) ◽  
pp. 252???262 ◽  
Author(s):  
James M. Williams ◽  
Mark Moran ◽  
Eugene J-M. A. Thonar ◽  
Robert B. Salter

Author(s):  
Akash Gupta ◽  
Kyung Chil Chung ◽  
Ryan J. Quigley ◽  
Bong Jae Jun ◽  
Thay Q. Lee

Articular cartilage damage is a common source of knee pain that can be treated with autologous chondrocyte implantation (ACI). Fixation of the scaffolds can be accomplished by various means with bone sutures being the most effective. The purpose of this study was to evaluate the fixation of a new scaffold with three bone sutures after cycling with continuous passive motion (CPM). Two defects, each of 20mm diameter and 5mm depth, were created per knee and the scaffold was fixed with three bone sutures at the 12 o’clock, 4 o’clock and 8 o’clock positions. Knees were then cycled from 0 degrees to 74 degrees to 0 degrees on a CPM machine for a total of 210 cycles and the scaffolds were then evaluated for fixation, fraying and delaminations. All scaffolds were noted to have remained fixed inside the defect. Fraying occurred in 16 out of the 20 scaffolds and delaminations occurred in 12 out of the 20. Only two scaffolds were completely free of both fraying and delaminations. Fraying occurred in 32.5% of the circumference of medial scaffolds while only 15.0% in lateral scaffolds. Fraying occurred mostly over flush areas and the least over recessed areas. Overall, three bone sutures provided excellent fixation of this scaffold. If at all possible, the scaffold should be recessed into the defect to minimize the amount of fraying that occurs.


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