Behavioral response profiles following drug challenge with dopamine receptor subtype agonists and antagonists in developing rat

2003 ◽  
Vol 25 (3) ◽  
pp. 311-328 ◽  
Author(s):  
Sonya K. Sobrian ◽  
Barbara L. Jones ◽  
Shiny Varghese ◽  
R.Robert Holson
Keyword(s):  
Dopamine Receptor ◽  
Behavioral Response ◽  
Receptor Subtype ◽  
Response Profiles ◽  
Drug Challenge ◽  
Developing Rat

scholarly journals Ghrelin Amplifies Dopamine Signaling by Cross Talk Involving Formation of Growth Hormone Secretagogue Receptor/Dopamine Receptor Subtype 1 Heterodimers

2006 ◽  
Vol 20 (8) ◽  
pp. 1772-1785 ◽  
Author(s):  
Hong Jiang ◽  
Lorena Betancourt ◽  
Roy G. Smith
Keyword(s):  
Dopamine Receptor ◽  
Fluorescent Protein ◽  
Green Fluorescent Protein Fluorescence ◽  
Receptor Subtype ◽  
Protein Fluorescence ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Dopamine Signaling

Abstract Our objective is to determine the neuromodulatory role of ghrelin in the brain. To identify neurons that express the ghrelin receptor [GH secretagogue receptor (GHS-R)], we generated GHS-R-IRES-tauGFP mice by gene targeting. Neurons expressing the GHS-R exhibit green fluorescence and are clearly evident in the hypothalamus, hippocampus, cortex, and midbrain. Using immunohistochemistry in combination with green fluorescent protein fluorescence, we identified neurons that coexpress the dopamine receptor subtype 1 (D1R) and GHS-R. The potential physiological relevance of coexpression of these two receptors and the direct effect of ghrelin on dopamine signaling was investigated in vitro. Activation of GHS-R by ghrelin amplifies dopamine/D1R-induced cAMP accumulation. Intriguingly, amplification involves a switch in G protein coupling of the GHS-R from Gα11/q to Gαi/o by a mechanism consistent with agonist-dependent formation of GHS-R/D1R heterodimers. Most importantly, these results indicate that ghrelin has the potential to amplify dopamine signaling selectively in neurons that coexpress D1R and GHS-R.

Dopamine receptor subtype imbalance in schizophrenia

Life Sciences ◽  
1987 ◽  
Vol 40 (15) ◽  
pp. 1487-1497 ◽  
Author(s):  
Ellen J. Hess ◽  
H. Stefan Bracha ◽  
Joel E. Kleinman ◽  
Ian Creese
Keyword(s):  
Dopamine Receptor ◽  
Receptor Subtype

scholarly journals High expression of dopamine receptor subtype 2 in a large series of neuroendocrine tumors

2008 ◽  
Vol 7 (12) ◽  
pp. 1970-1978 ◽  
Author(s):  
Erika Grossrubatscher ◽  
Silvio Veronese ◽  
Paolo Dalino Ciaramella ◽  
Raffaele Pugliese ◽  
Marco Boniardi ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Neuroendocrine Tumors ◽  
Large Series ◽  
High Expression ◽  
Receptor Subtype

The role of the D3 dopamine receptor subtype in behaviour

1997 ◽  
Vol 42 (1) ◽  
pp. 19S
Author(s):  
D.J. Sanger ◽  
R. Depoortere ◽  
Gh. Perrault
Keyword(s):  
Dopamine Receptor ◽  
Receptor Subtype
Sign in / Sign up

Export Citation Format

Share Document